The Combination of Immunosuppression and Carrier Cells Significantly Enhances the Efficacy of Oncolytic Poxvirus in the Pre-Immunized Host

Pre-existing anti-poxvirus immunity in cancer patients presents a severe barrier to poxvirus-mediated oncolytic virotherapy. We have explored strategies of immunosuppression (IS) and/or immune evasion for efficient delivery of an oncolytic vaccinia virus (vvDD) to tumors in the pre-immunized mice. T...

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Detalles Bibliográficos
Autores principales: Guo, Z. Sheng, Parimi, Vamsi, O'Malley, Mark E., Thirunavukarasu, Pragatheeshwar, Sathaiah, Magesh, Austin, Frances, Bartlett, David L.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982886/
https://www.ncbi.nlm.nih.gov/pubmed/20703311
http://dx.doi.org/10.1038/gt.2010.104

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