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Squash preparation: A reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors

BACKGROUND: Intraoperative cytology is an important diagnostic modality improving on the accuracy of the frozen sections. It has shown to play an important role especially in the intraoperative diagnosis of central nervous system tumors. AIM: To study the diagnostic accuracy of squash preparation an...

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Autores principales: Mitra, Sumit, Kumar, Mohan, Sharma, Vivek, Mukhopadhyay, Debasis
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983079/
https://www.ncbi.nlm.nih.gov/pubmed/21187881
http://dx.doi.org/10.4103/0970-9371.71870
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author Mitra, Sumit
Kumar, Mohan
Sharma, Vivek
Mukhopadhyay, Debasis
author_facet Mitra, Sumit
Kumar, Mohan
Sharma, Vivek
Mukhopadhyay, Debasis
author_sort Mitra, Sumit
collection PubMed
description BACKGROUND: Intraoperative cytology is an important diagnostic modality improving on the accuracy of the frozen sections. It has shown to play an important role especially in the intraoperative diagnosis of central nervous system tumors. AIM: To study the diagnostic accuracy of squash preparation and frozen section (FS) in the intraoperative diagnosis of central nervous system (CNS) tumors. MATERIALS AND METHODS: This prospective study of 114 patients with CNS tumors was conducted over a period of 18 months (September 2004 to February 2006). The cytological preparations were stained by the quick Papanicolaou method. The squash interpretation and FS diagnosis were later compared with the paraffin section diagnosis. RESULTS: Of the 114 patients, cytological diagnosis was offered in 96 cases. Eighteen nonneoplastic or noncontributory cases were excluded. Using hematoxylin and eosin-stained histopathology sections as the gold standard, the diagnostic accuracy of cytology was 88.5% (85/96) and the accuracy on FS diagnosis was 90.6% (87/96). Among these cases, gliomas formed the largest category of tumors (55.2%). The cytological accuracy in this group was 84.9% (45/53) and the comparative FS figure was 86.8% (46/53). In cases where the smear and the FS diagnosis did not match, the latter opinion was offered. CONCLUSIONS: Squash preparation is a reliable, rapid and easy method and can be used as a complement to FS in the intraoperative diagnosis of CNS tumors.
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spelling pubmed-29830792010-12-23 Squash preparation: A reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors Mitra, Sumit Kumar, Mohan Sharma, Vivek Mukhopadhyay, Debasis J Cytol Original Article BACKGROUND: Intraoperative cytology is an important diagnostic modality improving on the accuracy of the frozen sections. It has shown to play an important role especially in the intraoperative diagnosis of central nervous system tumors. AIM: To study the diagnostic accuracy of squash preparation and frozen section (FS) in the intraoperative diagnosis of central nervous system (CNS) tumors. MATERIALS AND METHODS: This prospective study of 114 patients with CNS tumors was conducted over a period of 18 months (September 2004 to February 2006). The cytological preparations were stained by the quick Papanicolaou method. The squash interpretation and FS diagnosis were later compared with the paraffin section diagnosis. RESULTS: Of the 114 patients, cytological diagnosis was offered in 96 cases. Eighteen nonneoplastic or noncontributory cases were excluded. Using hematoxylin and eosin-stained histopathology sections as the gold standard, the diagnostic accuracy of cytology was 88.5% (85/96) and the accuracy on FS diagnosis was 90.6% (87/96). Among these cases, gliomas formed the largest category of tumors (55.2%). The cytological accuracy in this group was 84.9% (45/53) and the comparative FS figure was 86.8% (46/53). In cases where the smear and the FS diagnosis did not match, the latter opinion was offered. CONCLUSIONS: Squash preparation is a reliable, rapid and easy method and can be used as a complement to FS in the intraoperative diagnosis of CNS tumors. Medknow Publications 2010-07 /pmc/articles/PMC2983079/ /pubmed/21187881 http://dx.doi.org/10.4103/0970-9371.71870 Text en © Journal of Cytology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mitra, Sumit
Kumar, Mohan
Sharma, Vivek
Mukhopadhyay, Debasis
Squash preparation: A reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors
title Squash preparation: A reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors
title_full Squash preparation: A reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors
title_fullStr Squash preparation: A reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors
title_full_unstemmed Squash preparation: A reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors
title_short Squash preparation: A reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors
title_sort squash preparation: a reliable diagnostic tool in the intraoperative diagnosis of central nervous system tumors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983079/
https://www.ncbi.nlm.nih.gov/pubmed/21187881
http://dx.doi.org/10.4103/0970-9371.71870
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