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Role of scrape cytology in the intraoperative diagnosis of tumor

BACKGROUND: Rapid diagnosis of surgically removed specimens has created many controversies and a single completely reliable method has not yet been developed. Histopathology of a paraffin section remains the ultimate gold standard in tissue diagnosis. Frozen section is routinely used by the surgical...

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Autores principales: Kolte, Sachin S, Satarkar, Rahul N
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983080/
https://www.ncbi.nlm.nih.gov/pubmed/21187882
http://dx.doi.org/10.4103/0970-9371.71871
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author Kolte, Sachin S
Satarkar, Rahul N
author_facet Kolte, Sachin S
Satarkar, Rahul N
author_sort Kolte, Sachin S
collection PubMed
description BACKGROUND: Rapid diagnosis of surgically removed specimens has created many controversies and a single completely reliable method has not yet been developed. Histopathology of a paraffin section remains the ultimate gold standard in tissue diagnosis. Frozen section is routinely used by the surgical pathology laboratories for intraoperative diagnosis. The use of either frozen section or cytological examination alone has an acceptable rate (93–97%) of correct diagnosis, with regard to interpretation of benign versus malignant. AIM: To evaluate the utility of scrape cytology for the rapid diagnosis of surgically removed tumors and its utilisation for learning cytopathology. MATERIALS AND METHODS: 75 surgically removed specimens from various organs and systems were studied. Scrapings were taken from each specimen before formalin fixation and stained by modified rapid Papanicolaou staining. RESULTS: Of the 75 cases studied, 73 could be correctly differentiated into benign and malignant tumors, with an accuracy rate of 97.3%. CONCLUSIONS: Intraoperative scrape cytology is useful for intraoperative diagnosis of tumor, where facilities for frozen section are not available. The skill and expertise developed by routinely practicing intraoperative cytology can be applied to the interpretation of fine needle aspirate smears. Thus, apart from its diagnostic role, intraoperative cytology can become a very useful learning tool in the field of cytopathology.
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spelling pubmed-29830802010-12-23 Role of scrape cytology in the intraoperative diagnosis of tumor Kolte, Sachin S Satarkar, Rahul N J Cytol Original Article BACKGROUND: Rapid diagnosis of surgically removed specimens has created many controversies and a single completely reliable method has not yet been developed. Histopathology of a paraffin section remains the ultimate gold standard in tissue diagnosis. Frozen section is routinely used by the surgical pathology laboratories for intraoperative diagnosis. The use of either frozen section or cytological examination alone has an acceptable rate (93–97%) of correct diagnosis, with regard to interpretation of benign versus malignant. AIM: To evaluate the utility of scrape cytology for the rapid diagnosis of surgically removed tumors and its utilisation for learning cytopathology. MATERIALS AND METHODS: 75 surgically removed specimens from various organs and systems were studied. Scrapings were taken from each specimen before formalin fixation and stained by modified rapid Papanicolaou staining. RESULTS: Of the 75 cases studied, 73 could be correctly differentiated into benign and malignant tumors, with an accuracy rate of 97.3%. CONCLUSIONS: Intraoperative scrape cytology is useful for intraoperative diagnosis of tumor, where facilities for frozen section are not available. The skill and expertise developed by routinely practicing intraoperative cytology can be applied to the interpretation of fine needle aspirate smears. Thus, apart from its diagnostic role, intraoperative cytology can become a very useful learning tool in the field of cytopathology. Medknow Publications 2010-07 /pmc/articles/PMC2983080/ /pubmed/21187882 http://dx.doi.org/10.4103/0970-9371.71871 Text en © Journal of Cytology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kolte, Sachin S
Satarkar, Rahul N
Role of scrape cytology in the intraoperative diagnosis of tumor
title Role of scrape cytology in the intraoperative diagnosis of tumor
title_full Role of scrape cytology in the intraoperative diagnosis of tumor
title_fullStr Role of scrape cytology in the intraoperative diagnosis of tumor
title_full_unstemmed Role of scrape cytology in the intraoperative diagnosis of tumor
title_short Role of scrape cytology in the intraoperative diagnosis of tumor
title_sort role of scrape cytology in the intraoperative diagnosis of tumor
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983080/
https://www.ncbi.nlm.nih.gov/pubmed/21187882
http://dx.doi.org/10.4103/0970-9371.71871
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