β-Polymorph of phenazepam: a powder study

The title compound [systematic name: 7-bromo-5-(2-chloro­phen­yl)-1H-1,4-benzodiazepin-2(3H)-one] (β-polymorph), C(15)H(10)BrClN(2)O, has been obtained via cryomodification of the known α-polymorph of phenazepam [Karapetyan et al. (1979 ▶). Bioorg. Khim. 5, 1684–1690]. In both polymorphs, the mol­ec...

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Autores principales: Sergeev, Gleb B., Sergeev, Boris M., Morosov, Yurii N., Chernyshev, Vladimir V.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983154/
https://www.ncbi.nlm.nih.gov/pubmed/21587597
http://dx.doi.org/10.1107/S1600536810037402
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author Sergeev, Gleb B.
Sergeev, Boris M.
Morosov, Yurii N.
Chernyshev, Vladimir V.
author_facet Sergeev, Gleb B.
Sergeev, Boris M.
Morosov, Yurii N.
Chernyshev, Vladimir V.
author_sort Sergeev, Gleb B.
collection PubMed
description The title compound [systematic name: 7-bromo-5-(2-chloro­phen­yl)-1H-1,4-benzodiazepin-2(3H)-one] (β-polymorph), C(15)H(10)BrClN(2)O, has been obtained via cryomodification of the known α-polymorph of phenazepam [Karapetyan et al. (1979 ▶). Bioorg. Khim. 5, 1684–1690]. In both polymorphs, the mol­ecules, which differ only in the dihedral angles between the aromatic rings [75.4 (2)° and 86.2 (3)° in the α- and β-polymorphs, respectively], are linked into centrosymmetric dimers via N—H⋯O hydrogen bonds. In the crystal structure of the β-polymorph, weak inter­molecular C—H⋯O hydrogen bonds further link these dimers into layers parallel to bc plane.
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spelling pubmed-29831542010-12-30 β-Polymorph of phenazepam: a powder study Sergeev, Gleb B. Sergeev, Boris M. Morosov, Yurii N. Chernyshev, Vladimir V. Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound [systematic name: 7-bromo-5-(2-chloro­phen­yl)-1H-1,4-benzodiazepin-2(3H)-one] (β-polymorph), C(15)H(10)BrClN(2)O, has been obtained via cryomodification of the known α-polymorph of phenazepam [Karapetyan et al. (1979 ▶). Bioorg. Khim. 5, 1684–1690]. In both polymorphs, the mol­ecules, which differ only in the dihedral angles between the aromatic rings [75.4 (2)° and 86.2 (3)° in the α- and β-polymorphs, respectively], are linked into centrosymmetric dimers via N—H⋯O hydrogen bonds. In the crystal structure of the β-polymorph, weak inter­molecular C—H⋯O hydrogen bonds further link these dimers into layers parallel to bc plane. International Union of Crystallography 2010-09-25 /pmc/articles/PMC2983154/ /pubmed/21587597 http://dx.doi.org/10.1107/S1600536810037402 Text en © Sergeev et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Sergeev, Gleb B.
Sergeev, Boris M.
Morosov, Yurii N.
Chernyshev, Vladimir V.
β-Polymorph of phenazepam: a powder study
title β-Polymorph of phenazepam: a powder study
title_full β-Polymorph of phenazepam: a powder study
title_fullStr β-Polymorph of phenazepam: a powder study
title_full_unstemmed β-Polymorph of phenazepam: a powder study
title_short β-Polymorph of phenazepam: a powder study
title_sort β-polymorph of phenazepam: a powder study
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983154/
https://www.ncbi.nlm.nih.gov/pubmed/21587597
http://dx.doi.org/10.1107/S1600536810037402
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