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Trihexyphenidyl hydro­chloride: a powder diffraction study

In the cation of the title compound [systematic name: 1-(3-cyclo­hexyl-3-hy­droxy-3-phenyl­prop­yl)piperidinium chloride], C(20)H(32)NO(+)·Cl(−), the cyclo­hexyl and piperidine rings are in chair conformations. In the crystal structure, cations and anions are linked into chains along the c-axis dire...

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Detalles Bibliográficos
Autores principales: Maccaroni, Elisabetta, Malpezzi, Luciana, Masciocchi, Norberto
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983296/
https://www.ncbi.nlm.nih.gov/pubmed/21587506
http://dx.doi.org/10.1107/S1600536810035294
Descripción
Sumario:In the cation of the title compound [systematic name: 1-(3-cyclo­hexyl-3-hy­droxy-3-phenyl­prop­yl)piperidinium chloride], C(20)H(32)NO(+)·Cl(−), the cyclo­hexyl and piperidine rings are in chair conformations. In the crystal structure, cations and anions are linked into chains along the c-axis direction via O—H⋯Cl and N—H⋯Cl hydrogen bonds. Weak inter­molecular C—H⋯Cl inter­actions link further these chains into layers parallel to the bc plane. The salt, obtained from a racemic solution, was found to crystallize in the chiral P2(1)2(1)2 space group, indicating that, in the absence of any evident chirality-inducing process, the polycrystalline powders consist of an equivalent mixture of R and S enanti­omers, forming a racemic conglomerate.