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Trihexyphenidyl hydrochloride: a powder diffraction study
In the cation of the title compound [systematic name: 1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)piperidinium chloride], C(20)H(32)NO(+)·Cl(−), the cyclohexyl and piperidine rings are in chair conformations. In the crystal structure, cations and anions are linked into chains along the c-axis dire...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983296/ https://www.ncbi.nlm.nih.gov/pubmed/21587506 http://dx.doi.org/10.1107/S1600536810035294 |
Sumario: | In the cation of the title compound [systematic name: 1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)piperidinium chloride], C(20)H(32)NO(+)·Cl(−), the cyclohexyl and piperidine rings are in chair conformations. In the crystal structure, cations and anions are linked into chains along the c-axis direction via O—H⋯Cl and N—H⋯Cl hydrogen bonds. Weak intermolecular C—H⋯Cl interactions link further these chains into layers parallel to the bc plane. The salt, obtained from a racemic solution, was found to crystallize in the chiral P2(1)2(1)2 space group, indicating that, in the absence of any evident chirality-inducing process, the polycrystalline powders consist of an equivalent mixture of R and S enantiomers, forming a racemic conglomerate. |
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