4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-(4-cyano­phen­yl)piperazine-1-carboxamide

In the title compound, C(28)H(22)ClFN(6)O(2), the piperazine ring adopts a chair conformation and the least-squares plane through the four coplanar atoms forms dihedral angles of 69.37 (13) and 56.56 (12)°, respectively, with the pyrazole and cyano­phenyl rings. The dihedral angles formed between th...

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Detalles Bibliográficos
Autores principales: Loh, Wan-Sin, Fun, Hoong-Kun, Ragavan, R. Venkat, Vijayakumar, V., Venkatesh, M.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983346/
https://www.ncbi.nlm.nih.gov/pubmed/21587549
http://dx.doi.org/10.1107/S1600536810036159
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author Loh, Wan-Sin
Fun, Hoong-Kun
Ragavan, R. Venkat
Vijayakumar, V.
Venkatesh, M.
author_facet Loh, Wan-Sin
Fun, Hoong-Kun
Ragavan, R. Venkat
Vijayakumar, V.
Venkatesh, M.
author_sort Loh, Wan-Sin
collection PubMed
description In the title compound, C(28)H(22)ClFN(6)O(2), the piperazine ring adopts a chair conformation and the least-squares plane through the four coplanar atoms forms dihedral angles of 69.37 (13) and 56.56 (12)°, respectively, with the pyrazole and cyano­phenyl rings. The dihedral angles formed between the pyrazole and the attached fluoro- and chloro­phenyl rings are 34.16 (10) and 73.27 (12)°, respectively. In the crystal, inter­molecular N—H⋯O, C—H⋯N and C—H⋯O hydrogen bonds link the mol­ecules into sheets parallel to the ac plane.
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spelling pubmed-29833462010-12-30 4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-(4-cyano­phen­yl)piperazine-1-carboxamide Loh, Wan-Sin Fun, Hoong-Kun Ragavan, R. Venkat Vijayakumar, V. Venkatesh, M. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(28)H(22)ClFN(6)O(2), the piperazine ring adopts a chair conformation and the least-squares plane through the four coplanar atoms forms dihedral angles of 69.37 (13) and 56.56 (12)°, respectively, with the pyrazole and cyano­phenyl rings. The dihedral angles formed between the pyrazole and the attached fluoro- and chloro­phenyl rings are 34.16 (10) and 73.27 (12)°, respectively. In the crystal, inter­molecular N—H⋯O, C—H⋯N and C—H⋯O hydrogen bonds link the mol­ecules into sheets parallel to the ac plane. International Union of Crystallography 2010-09-15 /pmc/articles/PMC2983346/ /pubmed/21587549 http://dx.doi.org/10.1107/S1600536810036159 Text en © Loh et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Loh, Wan-Sin
Fun, Hoong-Kun
Ragavan, R. Venkat
Vijayakumar, V.
Venkatesh, M.
4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-(4-cyano­phen­yl)piperazine-1-carboxamide
title 4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-(4-cyano­phen­yl)piperazine-1-carboxamide
title_full 4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-(4-cyano­phen­yl)piperazine-1-carboxamide
title_fullStr 4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-(4-cyano­phen­yl)piperazine-1-carboxamide
title_full_unstemmed 4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-(4-cyano­phen­yl)piperazine-1-carboxamide
title_short 4-{[5-(4-Chloro­phen­yl)-1-(4-fluoro­phen­yl)-1H-pyrazol-3-yl]carbon­yl}-N-(4-cyano­phen­yl)piperazine-1-carboxamide
title_sort 4-{[5-(4-chloro­phen­yl)-1-(4-fluoro­phen­yl)-1h-pyrazol-3-yl]carbon­yl}-n-(4-cyano­phen­yl)piperazine-1-carboxamide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983346/
https://www.ncbi.nlm.nih.gov/pubmed/21587549
http://dx.doi.org/10.1107/S1600536810036159
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AT funhoongkun 454chlorophenyl14fluorophenyl1hpyrazol3ylcarbonyln4cyanophenylpiperazine1carboxamide
AT ragavanrvenkat 454chlorophenyl14fluorophenyl1hpyrazol3ylcarbonyln4cyanophenylpiperazine1carboxamide
AT vijayakumarv 454chlorophenyl14fluorophenyl1hpyrazol3ylcarbonyln4cyanophenylpiperazine1carboxamide
AT venkateshm 454chlorophenyl14fluorophenyl1hpyrazol3ylcarbonyln4cyanophenylpiperazine1carboxamide

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