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Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors
Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983444/ https://www.ncbi.nlm.nih.gov/pubmed/20959030 http://dx.doi.org/10.1186/scrt31 |
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author | Boeuf, Stephane Richter, Wiltrud |
author_facet | Boeuf, Stephane Richter, Wiltrud |
author_sort | Boeuf, Stephane |
collection | PubMed |
description | Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from being understood. Different sources of MSCs have been considered for cartilage tissue engineering, mainly based on criteria of availability, as for adipose tissue, or of proximity to cartilage and the joint environment in vivo, as for bone marrow and synovial tissues. Focussing on human MSCs, this review will provide an overview of studies featuring comparative analysis of the chondrogenic differentiation of MSCs from different sources. In particular, it will examine the influence of the cells' origin on the requirements for the induction of chondrogenesis and on the phenotype achieved by the cells after differentiation. |
format | Text |
id | pubmed-2983444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29834442011-10-13 Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors Boeuf, Stephane Richter, Wiltrud Stem Cell Res Ther Review Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from being understood. Different sources of MSCs have been considered for cartilage tissue engineering, mainly based on criteria of availability, as for adipose tissue, or of proximity to cartilage and the joint environment in vivo, as for bone marrow and synovial tissues. Focussing on human MSCs, this review will provide an overview of studies featuring comparative analysis of the chondrogenic differentiation of MSCs from different sources. In particular, it will examine the influence of the cells' origin on the requirements for the induction of chondrogenesis and on the phenotype achieved by the cells after differentiation. BioMed Central 2010-10-13 /pmc/articles/PMC2983444/ /pubmed/20959030 http://dx.doi.org/10.1186/scrt31 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Review Boeuf, Stephane Richter, Wiltrud Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors |
title | Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors |
title_full | Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors |
title_fullStr | Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors |
title_full_unstemmed | Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors |
title_short | Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors |
title_sort | chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983444/ https://www.ncbi.nlm.nih.gov/pubmed/20959030 http://dx.doi.org/10.1186/scrt31 |
work_keys_str_mv | AT boeufstephane chondrogenesisofmesenchymalstemcellsroleoftissuesourceandinducingfactors AT richterwiltrud chondrogenesisofmesenchymalstemcellsroleoftissuesourceandinducingfactors |