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4-[(2,5-Dimethyl-1,3-thiazol-4-yl)methyl]-4-hydroxy-2-methylisoquinoline-1,3(2H,4H)-dione
In the title isoquinolinedione compound, C(16)H(16)N(2)O(3)S, the piperidine ring in the tetrahydroisoquinoline ring system adopts a half-boat conformation. The essentially planar thiazole ring [maximum deviation = 0.007 (2) Å] makes a dihedral angle of 34.49 (7)° with the mean plane through the...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983771/ https://www.ncbi.nlm.nih.gov/pubmed/21580766 http://dx.doi.org/10.1107/S1600536810011141 |
Sumario: | In the title isoquinolinedione compound, C(16)H(16)N(2)O(3)S, the piperidine ring in the tetrahydroisoquinoline ring system adopts a half-boat conformation. The essentially planar thiazole ring [maximum deviation = 0.007 (2) Å] makes a dihedral angle of 34.49 (7)° with the mean plane through the tetrahydroisoquinoline ring system. In the crystal structure, two neighbouring molecules are linked via pairs of O—H⋯N and C—H⋯O hydrogen bonds into inversion-related dimers incorporating R (2) (2)(9) hydrogen-bond ring motifs. These dimers are further linked by weak intermolecular C—H⋯π interactions. |
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