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4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2H,4H)-dione

In the title isoquinolinedione derivative, C(16)H(16)N(2)O(4), the piperidine ring in the tetra­hydro­isoquinoline unit adopts a half-boat conformation. The essentially planar oxazole ring [maximum deviation = 0.004 (2) Å] is inclined at a dihedral angle of 36.00 (8)° to the tetra­hydro­isoquinoline...

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Detalles Bibliográficos
Autores principales: Fun, Hoong-Kun, Goh, Jia Hao, Yu, Haitao, Zhang, Yan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983926/
https://www.ncbi.nlm.nih.gov/pubmed/21580572
http://dx.doi.org/10.1107/S1600536810007397
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author Fun, Hoong-Kun
Goh, Jia Hao
Yu, Haitao
Zhang, Yan
author_facet Fun, Hoong-Kun
Goh, Jia Hao
Yu, Haitao
Zhang, Yan
author_sort Fun, Hoong-Kun
collection PubMed
description In the title isoquinolinedione derivative, C(16)H(16)N(2)O(4), the piperidine ring in the tetra­hydro­isoquinoline unit adopts a half-boat conformation. The essentially planar oxazole ring [maximum deviation = 0.004 (2) Å] is inclined at a dihedral angle of 36.00 (8)° to the tetra­hydro­isoquinoline unit. In the crystal structure, pairs of inter­molecular C—H⋯O and O—H⋯N inter­actions link the mol­ecules into chains incorporating R (2) (2)(9) ring motifs. Two neighbouring chains are further inter­connected by inter­molecular C—H⋯O inter­actions into chains two mol­ecules wide along the a axis.
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spelling pubmed-29839262010-12-30 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2H,4H)-dione Fun, Hoong-Kun Goh, Jia Hao Yu, Haitao Zhang, Yan Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title isoquinolinedione derivative, C(16)H(16)N(2)O(4), the piperidine ring in the tetra­hydro­isoquinoline unit adopts a half-boat conformation. The essentially planar oxazole ring [maximum deviation = 0.004 (2) Å] is inclined at a dihedral angle of 36.00 (8)° to the tetra­hydro­isoquinoline unit. In the crystal structure, pairs of inter­molecular C—H⋯O and O—H⋯N inter­actions link the mol­ecules into chains incorporating R (2) (2)(9) ring motifs. Two neighbouring chains are further inter­connected by inter­molecular C—H⋯O inter­actions into chains two mol­ecules wide along the a axis. International Union of Crystallography 2010-03-03 /pmc/articles/PMC2983926/ /pubmed/21580572 http://dx.doi.org/10.1107/S1600536810007397 Text en © Fun et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Fun, Hoong-Kun
Goh, Jia Hao
Yu, Haitao
Zhang, Yan
4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2H,4H)-dione
title 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2H,4H)-dione
title_full 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2H,4H)-dione
title_fullStr 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2H,4H)-dione
title_full_unstemmed 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2H,4H)-dione
title_short 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2H,4H)-dione
title_sort 4-[(2,4-dimethyl-1,3-oxazol-5-yl)meth­yl]-4-hydr­oxy-2-methyl­isoquinoline-1,3(2h,4h)-dione
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983926/
https://www.ncbi.nlm.nih.gov/pubmed/21580572
http://dx.doi.org/10.1107/S1600536810007397
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