Dual Mechanisms of HNO Generation by a Nitroxyl Prodrug of the Diazeniumdiolate (NONOate) Class

[Image: see text] Here we describe a novel caged form of the highly reactive bioeffector molecule, nitroxyl (HNO). Reacting the labile nitric oxide (NO)- and HNO-generating salt of structure iPrHN−N(O)=NO(−)Na(+) (1, IPA/NO) with BrCH(2)OAc produced a stable derivative of structure iPrHN-N(O)=NO−CH(...

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Detalles Bibliográficos
Autores principales: Andrei, Daniela, Salmon, Debra J., Donzelli, Sonia, Wahab, Azadeh, Klose, John R., Citro, Michael L., Saavedra, Joseph E., Wink, David A., Miranda, Katrina M., Keefer, Larry K.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984372/
https://www.ncbi.nlm.nih.gov/pubmed/21033665
http://dx.doi.org/10.1021/ja106552p

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