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Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies

BACKGROUND: YN968D1 (Apatinib) selectively inhibits phosphorylation of VEGFR-2 and tumor angiogenesis in mice model. The study was conducted to determine the maximum tolerated dose (MTD), safety profile, pharmacokinetic variables, and antitumor activity in advanced solid malignancies. METHODS: This...

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Detalles Bibliográficos
Autores principales:	Li, Jin, Zhao, Xinmin, Chen, Lei, Guo, Haiyi, Lv, Fangfang, Jia, Ka, Yv, Ke, Wang, Fengqing, Li, Chuan, Qian, Jun, Zheng, Chunlei, Zuo, Yunxia
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984425/ https://www.ncbi.nlm.nih.gov/pubmed/20923544 http://dx.doi.org/10.1186/1471-2407-10-529

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