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Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury

Acute pain caused by musculoskeletal disorders is very common and has a significant negative impact on quality-of-life and societal costs. Many types of acute pain have been managed with traditional oral non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitors (coxibs...

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Detalles Bibliográficos
Autores principales: McCarberg, B H, Argoff, C E
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984542/
https://www.ncbi.nlm.nih.gov/pubmed/20666849
http://dx.doi.org/10.1111/j.1742-1241.2010.02474.x
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author McCarberg, B H
Argoff, C E
author_facet McCarberg, B H
Argoff, C E
author_sort McCarberg, B H
collection PubMed
description Acute pain caused by musculoskeletal disorders is very common and has a significant negative impact on quality-of-life and societal costs. Many types of acute pain have been managed with traditional oral non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitors (coxibs). Data from prospective, randomised controlled clinical trials and postmarketing surveillance indicate that use of oral traditional NSAIDs and coxibs is associated with an elevated risk of developing gastrointestinal, renovascular and/or cardiovascular adverse events (AEs). Increasing awareness of the AEs associated with NSAID therapy, including coxibs, has led many physicians and patients to reconsider use of these drugs and look for alternative treatment options. Treatment with NSAIDs via the topical route of administration has been shown to provide clinically effective analgesia at the site of application while minimising systemic absorption. The anti-inflammatory and analgesic potency of the traditional oral NSAID diclofenac, along with its physicochemical properties, makes it well suited for topical delivery. Several topical formulations of diclofenac have been developed. A topical patch containing diclofenac epolamine 1.3% (DETP, FLECTOR® Patch), approved for use in Europe in 1993, has recently been approved for use in the United States and is indicated for the treatment of acute pain caused by minor strains, sprains and contusions. In this article, we review the available clinical trial data for this product in the treatment of pain caused by soft tissue injury.
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spelling pubmed-29845422010-11-19 Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury McCarberg, B H Argoff, C E Int J Clin Pract Pain Medicine Acute pain caused by musculoskeletal disorders is very common and has a significant negative impact on quality-of-life and societal costs. Many types of acute pain have been managed with traditional oral non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitors (coxibs). Data from prospective, randomised controlled clinical trials and postmarketing surveillance indicate that use of oral traditional NSAIDs and coxibs is associated with an elevated risk of developing gastrointestinal, renovascular and/or cardiovascular adverse events (AEs). Increasing awareness of the AEs associated with NSAID therapy, including coxibs, has led many physicians and patients to reconsider use of these drugs and look for alternative treatment options. Treatment with NSAIDs via the topical route of administration has been shown to provide clinically effective analgesia at the site of application while minimising systemic absorption. The anti-inflammatory and analgesic potency of the traditional oral NSAID diclofenac, along with its physicochemical properties, makes it well suited for topical delivery. Several topical formulations of diclofenac have been developed. A topical patch containing diclofenac epolamine 1.3% (DETP, FLECTOR® Patch), approved for use in Europe in 1993, has recently been approved for use in the United States and is indicated for the treatment of acute pain caused by minor strains, sprains and contusions. In this article, we review the available clinical trial data for this product in the treatment of pain caused by soft tissue injury. Blackwell Publishing Ltd 2010-10 /pmc/articles/PMC2984542/ /pubmed/20666849 http://dx.doi.org/10.1111/j.1742-1241.2010.02474.x Text en Copyright © 2010 Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Pain Medicine
McCarberg, B H
Argoff, C E
Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury
title Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury
title_full Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury
title_fullStr Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury
title_full_unstemmed Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury
title_short Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury
title_sort topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury
topic Pain Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984542/
https://www.ncbi.nlm.nih.gov/pubmed/20666849
http://dx.doi.org/10.1111/j.1742-1241.2010.02474.x
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