Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma

The application of gene therapy for malignant gliomas is still under study and the use of specific vectors represents an important contribution. Here, we investigated bovine herpesvirus 4 (BoHV-4), which is non-pathogenic if injected into the rodent brain. We show that the vector can infect mouse, r...

Descripción completa

Detalles Bibliográficos
Autores principales: Redaelli, Marco, Mucignat-Caretta, Carla, Cavaggioni, Andrea, Caretta, Antonio, D'Avella, Domenico, Denaro, Luca, Cavirani, Sandro, Donofrio, Gaetano
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984596/
https://www.ncbi.nlm.nih.gov/pubmed/21047419
http://dx.doi.org/10.1186/1743-422X-7-298
_version_ 1782192122029408256
author Redaelli, Marco
Mucignat-Caretta, Carla
Cavaggioni, Andrea
Caretta, Antonio
D'Avella, Domenico
Denaro, Luca
Cavirani, Sandro
Donofrio, Gaetano
author_facet Redaelli, Marco
Mucignat-Caretta, Carla
Cavaggioni, Andrea
Caretta, Antonio
D'Avella, Domenico
Denaro, Luca
Cavirani, Sandro
Donofrio, Gaetano
author_sort Redaelli, Marco
collection PubMed
description The application of gene therapy for malignant gliomas is still under study and the use of specific vectors represents an important contribution. Here, we investigated bovine herpesvirus 4 (BoHV-4), which is non-pathogenic if injected into the rodent brain. We show that the vector can infect mouse, rat and human glioma cell lines and primary cultures obtained from human glioblastoma in vitro. BoHV-4 was injected into a tumour grown in rat brain. Although virus expression was scattered across the tumour mass, it was mainly located in the peripheral area of larger gliomas. These data support BoHV-4 as a candidate vector for glioma treatment.
format Text
id pubmed-2984596
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-29845962010-11-19 Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma Redaelli, Marco Mucignat-Caretta, Carla Cavaggioni, Andrea Caretta, Antonio D'Avella, Domenico Denaro, Luca Cavirani, Sandro Donofrio, Gaetano Virol J Short Report The application of gene therapy for malignant gliomas is still under study and the use of specific vectors represents an important contribution. Here, we investigated bovine herpesvirus 4 (BoHV-4), which is non-pathogenic if injected into the rodent brain. We show that the vector can infect mouse, rat and human glioma cell lines and primary cultures obtained from human glioblastoma in vitro. BoHV-4 was injected into a tumour grown in rat brain. Although virus expression was scattered across the tumour mass, it was mainly located in the peripheral area of larger gliomas. These data support BoHV-4 as a candidate vector for glioma treatment. BioMed Central 2010-11-03 /pmc/articles/PMC2984596/ /pubmed/21047419 http://dx.doi.org/10.1186/1743-422X-7-298 Text en Copyright ©2010 Redaelli et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Redaelli, Marco
Mucignat-Caretta, Carla
Cavaggioni, Andrea
Caretta, Antonio
D'Avella, Domenico
Denaro, Luca
Cavirani, Sandro
Donofrio, Gaetano
Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
title Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
title_full Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
title_fullStr Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
title_full_unstemmed Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
title_short Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
title_sort bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984596/
https://www.ncbi.nlm.nih.gov/pubmed/21047419
http://dx.doi.org/10.1186/1743-422X-7-298
work_keys_str_mv AT redaellimarco bovineherpesvirus4basedvectorasapotentialoncolyticvirusfortreatmentofglioma
AT mucignatcarettacarla bovineherpesvirus4basedvectorasapotentialoncolyticvirusfortreatmentofglioma
AT cavaggioniandrea bovineherpesvirus4basedvectorasapotentialoncolyticvirusfortreatmentofglioma
AT carettaantonio bovineherpesvirus4basedvectorasapotentialoncolyticvirusfortreatmentofglioma
AT davelladomenico bovineherpesvirus4basedvectorasapotentialoncolyticvirusfortreatmentofglioma
AT denaroluca bovineherpesvirus4basedvectorasapotentialoncolyticvirusfortreatmentofglioma
AT caviranisandro bovineherpesvirus4basedvectorasapotentialoncolyticvirusfortreatmentofglioma
AT donofriogaetano bovineherpesvirus4basedvectorasapotentialoncolyticvirusfortreatmentofglioma

Ejemplares similares