TP53 and MTOR crosstalk to regulate cellular senescence

The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quies...

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Detalles Bibliográficos
Autores principales: Galluzzi, Lorenzo, Kepp, Oliver, Kroemer, Guido
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984599/
https://www.ncbi.nlm.nih.gov/pubmed/20876940
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author Galluzzi, Lorenzo
Kepp, Oliver
Kroemer, Guido
author_facet Galluzzi, Lorenzo
Kepp, Oliver
Kroemer, Guido
author_sort Galluzzi, Lorenzo
collection PubMed
description The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53.
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spelling pubmed-29845992010-11-18 TP53 and MTOR crosstalk to regulate cellular senescence Galluzzi, Lorenzo Kepp, Oliver Kroemer, Guido Aging (Albany NY) Editorial The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53. Impact Journals LLC 2010-09-18 /pmc/articles/PMC2984599/ /pubmed/20876940 Text en Copyright: © 2010 Galluzzi et al.
spellingShingle Editorial
Galluzzi, Lorenzo
Kepp, Oliver
Kroemer, Guido
TP53 and MTOR crosstalk to regulate cellular senescence
title TP53 and MTOR crosstalk to regulate cellular senescence
title_full TP53 and MTOR crosstalk to regulate cellular senescence
title_fullStr TP53 and MTOR crosstalk to regulate cellular senescence
title_full_unstemmed TP53 and MTOR crosstalk to regulate cellular senescence
title_short TP53 and MTOR crosstalk to regulate cellular senescence
title_sort tp53 and mtor crosstalk to regulate cellular senescence
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984599/
https://www.ncbi.nlm.nih.gov/pubmed/20876940
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