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Adult-onset, short-term dietary restriction reduces cell senescence in mice
Dietary restriction (DR) extends the lifespan of a wide variety of species and reduces the incidence of major age-related diseases. Cell senescence has been proposed as one causal mechanism for tissue and organism ageing. We show for the first time that adult-onset, short-term DR reduced frequencies...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984605/ https://www.ncbi.nlm.nih.gov/pubmed/20844316 |
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author | Wang, Chunfang Maddick, Mandy Miwa, Satomi Jurk, Diana Czapiewski, Rafal Saretzki, Gabriele Langie, Sabine A.S. Godschalk, Roger W.L. Cameron, Kerry von Zglinicki, Thomas |
author_facet | Wang, Chunfang Maddick, Mandy Miwa, Satomi Jurk, Diana Czapiewski, Rafal Saretzki, Gabriele Langie, Sabine A.S. Godschalk, Roger W.L. Cameron, Kerry von Zglinicki, Thomas |
author_sort | Wang, Chunfang |
collection | PubMed |
description | Dietary restriction (DR) extends the lifespan of a wide variety of species and reduces the incidence of major age-related diseases. Cell senescence has been proposed as one causal mechanism for tissue and organism ageing. We show for the first time that adult-onset, short-term DR reduced frequencies of senescent cells in the small intestinal epithelium and liver of mice, which are tissues known to accumulate increased numbers of senescent cells with advancing age. This reduction was associated with improved telomere maintenance without increased telomerase activity. We also found a decrease in cumulative oxidative stress markers in the same compartments despite absence of significant changes in steady-state oxidative stress markers at the whole tissue level. The data suggest the possibility that reduction of cell senescence may be a primary consequence of DR which in turn may explain known effects of DR such as improved mitochondrial function and reduced production of reactive oxygen species. |
format | Text |
id | pubmed-2984605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-29846052010-11-18 Adult-onset, short-term dietary restriction reduces cell senescence in mice Wang, Chunfang Maddick, Mandy Miwa, Satomi Jurk, Diana Czapiewski, Rafal Saretzki, Gabriele Langie, Sabine A.S. Godschalk, Roger W.L. Cameron, Kerry von Zglinicki, Thomas Aging (Albany NY) Research Paper Dietary restriction (DR) extends the lifespan of a wide variety of species and reduces the incidence of major age-related diseases. Cell senescence has been proposed as one causal mechanism for tissue and organism ageing. We show for the first time that adult-onset, short-term DR reduced frequencies of senescent cells in the small intestinal epithelium and liver of mice, which are tissues known to accumulate increased numbers of senescent cells with advancing age. This reduction was associated with improved telomere maintenance without increased telomerase activity. We also found a decrease in cumulative oxidative stress markers in the same compartments despite absence of significant changes in steady-state oxidative stress markers at the whole tissue level. The data suggest the possibility that reduction of cell senescence may be a primary consequence of DR which in turn may explain known effects of DR such as improved mitochondrial function and reduced production of reactive oxygen species. Impact Journals LLC 2010-09-11 /pmc/articles/PMC2984605/ /pubmed/20844316 Text en Copyright: © 2010 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Research Paper Wang, Chunfang Maddick, Mandy Miwa, Satomi Jurk, Diana Czapiewski, Rafal Saretzki, Gabriele Langie, Sabine A.S. Godschalk, Roger W.L. Cameron, Kerry von Zglinicki, Thomas Adult-onset, short-term dietary restriction reduces cell senescence in mice |
title | Adult-onset, short-term dietary restriction reduces cell senescence in mice |
title_full | Adult-onset, short-term dietary restriction reduces cell senescence in mice |
title_fullStr | Adult-onset, short-term dietary restriction reduces cell senescence in mice |
title_full_unstemmed | Adult-onset, short-term dietary restriction reduces cell senescence in mice |
title_short | Adult-onset, short-term dietary restriction reduces cell senescence in mice |
title_sort | adult-onset, short-term dietary restriction reduces cell senescence in mice |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984605/ https://www.ncbi.nlm.nih.gov/pubmed/20844316 |
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