Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans

Klotho exerts anti-aging properties in mammals in two different ways. While membrane-bound Klotho, which is primarily expressed in the kidney, acts as an obligate co-receptor of FGF23 to regulate phosphate homeostasis, secreted Klotho, resulting from the shedding of the KL1-KL2 ectodomain into the b...

Descripción completa

Detalles Bibliográficos
Autores principales: Château, Marie-Thérèse, Araiz, Caroline, Descamps, Simon, Galas, Simon
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984606/
https://www.ncbi.nlm.nih.gov/pubmed/20844315

Ejemplares similares

Ejemplares similares