Cargando…

ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells

We recently demonstrated that human embryonic stem cells (hESCs) utilize homologous recombination repair (HRR) as primary means of double-strand break (DSB) repair. We now show that hESCs also use nonhomologous end joining (NHEJ). NHEJ kinetics were several-fold slower in hESCs and neural progenitor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adams, Bret R., Hawkins, Amy J., Povirk, Lawrence F., Valerie, Kristoffer
Formato:	Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2010
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984607/ https://www.ncbi.nlm.nih.gov/pubmed/20844317

Ejemplares similares

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining
por: Waters, Crystal A., et al.
Publicado: (2014)

Phosphorylation in the serine/threonine 2609–2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts
por: Povirk, Lawrence F., et al.
Publicado: (2007)

The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line
por: Muraki, Keiko, et al.
Publicado: (2013)

Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases λ and μ for nonhomologous end joining in human whole-cell extracts
por: Akopiants, Konstantin, et al.
Publicado: (2009)

POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions
por: Yu, Yang, et al.
Publicado: (2017)

Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining
por: Hendrickson, Cynthia L., et al.
Publicado: (2010)

Nonhomologous DNA End Joining in Cell-Free Extracts
por: Sharma, Sheetal, et al.
Publicado: (2010)

The Minimal Bacillus subtilis Nonhomologous End Joining Repair Machinery
por: de Vega, Miguel
Publicado: (2013)

Evolutionary and Comparative Analysis of Bacterial Nonhomologous End Joining Repair
por: Sharda, Mohak, et al.
Publicado: (2020)

The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms
por: Garvin, Alexander J., et al.
Publicado: (2019)

Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?
por: Strande, Natasha Tiffany, et al.
Publicado: (2012)

A noncatalytic function of the ligation complex during nonhomologous end joining
por: Cottarel, Jessica, et al.
Publicado: (2013)

Cooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining
por: Tsai, Chun J., et al.
Publicado: (2013)

Reconstitution of Mycobacterium marinum Nonhomologous DNA End Joining Pathway in Leishmania
por: Zhang, Wen-Wei, et al.
Publicado: (2022)

De Novo CNV Formation in Mouse Embryonic Stem Cells Occurs in the Absence of Xrcc4-Dependent Nonhomologous End Joining
por: Arlt, Martin F., et al.
Publicado: (2012)

LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining
por: Lawrence, Katherine S., et al.
Publicado: (2016)

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways
por: Beck, Carole, et al.
Publicado: (2014)

Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination
por: Du, Likun, et al.
Publicado: (2008)

Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage
por: Pavlicek, Adam, et al.
Publicado: (2006)

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
por: Di Virgilio, Michela, et al.
Publicado: (2005)

Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts
por: Gassman, Natalie R., et al.
Publicado: (2012)

Efficient processing of abasic sites by bacterial nonhomologous end-joining Ku proteins
por: de Ory, Ana, et al.
Publicado: (2014)

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining
por: Keka, Islam Shamima, et al.
Publicado: (2015)

A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis
por: Löbrich, Markus, et al.
Publicado: (2017)

Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes
por: Nenarokova, Anna, et al.
Publicado: (2019)

Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell
por: Hussain, Suleman S, et al.
Publicado: (2021)

End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
por: Davis, Bryan J., et al.
Publicado: (2008)

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
por: Weterings, Eric, et al.
Publicado: (2007)

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
por: Couto, C. Anne-Marie, et al.
Publicado: (2011)

Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining
por: Ochi, Takashi, et al.
Publicado: (2010)

Dynamic Dependence on ATR and ATM for Double-Strand Break Repair in Human Embryonic Stem Cells and Neural Descendants
por: Adams, Bret R., et al.
Publicado: (2010)

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
por: Reid, Dylan A., et al.
Publicado: (2017)

Injection of an SV40 transcriptional terminator causes embryonic lethality: a possible zebrafish model for screening nonhomologous end-joining inhibitors
por: Yang, Zhe, et al.
Publicado: (2018)

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes
por: Saribasak, Huseyin, et al.
Publicado: (2011)

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation
por: Simsek, Deniz, et al.
Publicado: (2011)

BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
por: Han, Jinhua, et al.
Publicado: (2017)

A CRISPR-Assisted Nonhomologous End-Joining Strategy for Efficient Genome Editing in Mycobacterium tuberculosis
por: Yan, Mei-Yi, et al.
Publicado: (2020)

Inhibition of nonhomologous end joining‐mediated DNA repair enhances anti‐HBV CRISPR therapy
por: Murai, Kazuhiro, et al.
Publicado: (2022)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2pgnn3ecvl6nu8d47t72ioijsg