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Quantitative cardiovascular magnetic resonance for molecular imaging

Cardiovascular magnetic resonance (CMR) molecular imaging aims to identify and map the expression of important biomarkers on a cellular scale utilizing contrast agents that are specifically targeted to the biochemical signatures of disease and are capable of generating sufficient image contrast. In...

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Detalles Bibliográficos
Autores principales: Winter, Patrick M, Caruthers, Shelton D, Lanza, Gregory M, Wickline, Samuel A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987770/
https://www.ncbi.nlm.nih.gov/pubmed/21047411
http://dx.doi.org/10.1186/1532-429X-12-62
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author Winter, Patrick M
Caruthers, Shelton D
Lanza, Gregory M
Wickline, Samuel A
author_facet Winter, Patrick M
Caruthers, Shelton D
Lanza, Gregory M
Wickline, Samuel A
author_sort Winter, Patrick M
collection PubMed
description Cardiovascular magnetic resonance (CMR) molecular imaging aims to identify and map the expression of important biomarkers on a cellular scale utilizing contrast agents that are specifically targeted to the biochemical signatures of disease and are capable of generating sufficient image contrast. In some cases, the contrast agents may be designed to carry a drug payload or to be sensitive to important physiological factors, such as pH, temperature or oxygenation. In this review, examples will be presented that utilize a number of different molecular imaging quantification techniques, including measuring signal changes, calculating the area of contrast enhancement, mapping relaxation time changes or direct detection of contrast agents through multi-nuclear imaging or spectroscopy. The clinical application of CMR molecular imaging could offer far reaching benefits to patient populations, including early detection of therapeutic response, localizing ruptured atherosclerotic plaques, stratifying patients based on biochemical disease markers, tissue-specific drug delivery, confirmation and quantification of end-organ drug uptake, and noninvasive monitoring of disease recurrence. Eventually, such agents may play a leading role in reducing the human burden of cardiovascular disease, by providing early diagnosis, noninvasive monitoring and effective therapy with reduced side effects.
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spelling pubmed-29877702010-11-19 Quantitative cardiovascular magnetic resonance for molecular imaging Winter, Patrick M Caruthers, Shelton D Lanza, Gregory M Wickline, Samuel A J Cardiovasc Magn Reson Review Cardiovascular magnetic resonance (CMR) molecular imaging aims to identify and map the expression of important biomarkers on a cellular scale utilizing contrast agents that are specifically targeted to the biochemical signatures of disease and are capable of generating sufficient image contrast. In some cases, the contrast agents may be designed to carry a drug payload or to be sensitive to important physiological factors, such as pH, temperature or oxygenation. In this review, examples will be presented that utilize a number of different molecular imaging quantification techniques, including measuring signal changes, calculating the area of contrast enhancement, mapping relaxation time changes or direct detection of contrast agents through multi-nuclear imaging or spectroscopy. The clinical application of CMR molecular imaging could offer far reaching benefits to patient populations, including early detection of therapeutic response, localizing ruptured atherosclerotic plaques, stratifying patients based on biochemical disease markers, tissue-specific drug delivery, confirmation and quantification of end-organ drug uptake, and noninvasive monitoring of disease recurrence. Eventually, such agents may play a leading role in reducing the human burden of cardiovascular disease, by providing early diagnosis, noninvasive monitoring and effective therapy with reduced side effects. BioMed Central 2010-11-03 /pmc/articles/PMC2987770/ /pubmed/21047411 http://dx.doi.org/10.1186/1532-429X-12-62 Text en Copyright ©2010 Winter et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Winter, Patrick M
Caruthers, Shelton D
Lanza, Gregory M
Wickline, Samuel A
Quantitative cardiovascular magnetic resonance for molecular imaging
title Quantitative cardiovascular magnetic resonance for molecular imaging
title_full Quantitative cardiovascular magnetic resonance for molecular imaging
title_fullStr Quantitative cardiovascular magnetic resonance for molecular imaging
title_full_unstemmed Quantitative cardiovascular magnetic resonance for molecular imaging
title_short Quantitative cardiovascular magnetic resonance for molecular imaging
title_sort quantitative cardiovascular magnetic resonance for molecular imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987770/
https://www.ncbi.nlm.nih.gov/pubmed/21047411
http://dx.doi.org/10.1186/1532-429X-12-62
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