Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

Recent multi-dimensional approaches to the study of complex disease have revealed powerful insights into how genetic and epigenetic factors may underlie their aetiopathogenesis. We examined genotype-epigenotype interactions in the context of Type 2 Diabetes (T2D), focussing on known regions of genom...

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Detalles Bibliográficos
Autores principales: Bell, Christopher G., Finer, Sarah, Lindgren, Cecilia M., Wilson, Gareth A., Rakyan, Vardhman K., Teschendorff, Andrew E., Akan, Pelin, Stupka, Elia, Down, Thomas A., Prokopenko, Inga, Morison, Ian M., Mill, Jonathan, Pidsley, Ruth, Deloukas, Panos, Frayling, Timothy M., Hattersley, Andrew T., McCarthy, Mark I., Beck, Stephan, Hitman, Graham A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987816/
https://www.ncbi.nlm.nih.gov/pubmed/21124985
http://dx.doi.org/10.1371/journal.pone.0014040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987816/
https://www.ncbi.nlm.nih.gov/pubmed/21124985
http://dx.doi.org/10.1371/journal.pone.0014040

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