Altered DNA Methylation in Leukocytes with Trisomy 21

The primary abnormality in Down syndrome (DS), trisomy 21, is well known; but how this chromosomal gain produces the complex DS phenotype, including immune system defects, is not well understood. We profiled DNA methylation in total peripheral blood leukocytes (PBL) and T-lymphocytes from adults wit...

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Detalles Bibliográficos
Autores principales: Kerkel, Kristi, Schupf, Nicole, Hatta, Kota, Pang, Deborah, Salas, Martha, Kratz, Alexander, Minden, Mark, Murty, Vundavalli, Zigman, Warren B., Mayeux, Richard P., Jenkins, Edmund C., Torkamani, Ali, Schork, Nicholas J., Silverman, Wayne, Croy, B. Anne, Tycko, Benjamin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987931/
https://www.ncbi.nlm.nih.gov/pubmed/21124956
http://dx.doi.org/10.1371/journal.pgen.1001212

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