Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia

BACKGROUND: Rearrangement of the mixed-lineage leukemia gene (MLL) is found in 80% of infant acute lymphoblastic leukemia (ALL) and is associated with poor prognosis and resistance to glucocorticoids (GCs). We have recently observed that GC resistance in T-ALL cell lines is associated with a prolife...

Descripción completa

Detalles Bibliográficos
Autores principales: Beesley, Alex H, Rampellini, Janelle L, Palmer, Misty-Lee, Heng, Jasmin YS, Samuels, Amy L, Firth, Martin J, Ford, Jette, Kees, Ursula R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987983/
https://www.ncbi.nlm.nih.gov/pubmed/20979663
http://dx.doi.org/10.1186/1476-4598-9-284

Ejemplares similares

Ejemplares similares