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NOREPINEPHRINE AND SEROTONIN METABOLISM AND CLINICAL RESPONSE TO COMBINED IMIPRAMINE AND AMITRIPTYLINE THERAPY IN DEPRESSION
The present study was aimed to find out the alteration of NE and 5HT systems in depression, if so in the same direction or not and to find out the clinical response to combined therapy of Imipramine and Amitriptyline, both tricyclic antidepressants. The study group consisted of 39 depressives as def...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
1991
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988307/ https://www.ncbi.nlm.nih.gov/pubmed/21927500 |
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author | Palaniappun, V. Ramachandran, V. Somasundaram, O. |
author_facet | Palaniappun, V. Ramachandran, V. Somasundaram, O. |
author_sort | Palaniappun, V. |
collection | PubMed |
description | The present study was aimed to find out the alteration of NE and 5HT systems in depression, if so in the same direction or not and to find out the clinical response to combined therapy of Imipramine and Amitriptyline, both tricyclic antidepressants. The study group consisted of 39 depressives as defined by I. C. D. 9 and 17 normal controls. Hamilton Depression Rating Scale was used to assess the severity of depression initially and after clinical improvement with drugs. Urinary MHPG and CSF 5HIAA were estimated final] depressives as per the standard procedure. It was found that both urinary MHPG and CSF 5HIAA were lowered in depressives but when individual patients were analysed both were not altered in the same direction in a given individual. All the depressives showed equal therapautic response to combined administration of Imipramine and Amitripiyline. |
format | Text |
id | pubmed-2988307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29883072011-09-16 NOREPINEPHRINE AND SEROTONIN METABOLISM AND CLINICAL RESPONSE TO COMBINED IMIPRAMINE AND AMITRIPTYLINE THERAPY IN DEPRESSION Palaniappun, V. Ramachandran, V. Somasundaram, O. Indian J Psychiatry Original Article The present study was aimed to find out the alteration of NE and 5HT systems in depression, if so in the same direction or not and to find out the clinical response to combined therapy of Imipramine and Amitriptyline, both tricyclic antidepressants. The study group consisted of 39 depressives as defined by I. C. D. 9 and 17 normal controls. Hamilton Depression Rating Scale was used to assess the severity of depression initially and after clinical improvement with drugs. Urinary MHPG and CSF 5HIAA were estimated final] depressives as per the standard procedure. It was found that both urinary MHPG and CSF 5HIAA were lowered in depressives but when individual patients were analysed both were not altered in the same direction in a given individual. All the depressives showed equal therapautic response to combined administration of Imipramine and Amitripiyline. Medknow Publications 1991 /pmc/articles/PMC2988307/ /pubmed/21927500 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Palaniappun, V. Ramachandran, V. Somasundaram, O. NOREPINEPHRINE AND SEROTONIN METABOLISM AND CLINICAL RESPONSE TO COMBINED IMIPRAMINE AND AMITRIPTYLINE THERAPY IN DEPRESSION |
title | NOREPINEPHRINE AND SEROTONIN METABOLISM AND CLINICAL RESPONSE TO COMBINED IMIPRAMINE AND AMITRIPTYLINE THERAPY IN DEPRESSION |
title_full | NOREPINEPHRINE AND SEROTONIN METABOLISM AND CLINICAL RESPONSE TO COMBINED IMIPRAMINE AND AMITRIPTYLINE THERAPY IN DEPRESSION |
title_fullStr | NOREPINEPHRINE AND SEROTONIN METABOLISM AND CLINICAL RESPONSE TO COMBINED IMIPRAMINE AND AMITRIPTYLINE THERAPY IN DEPRESSION |
title_full_unstemmed | NOREPINEPHRINE AND SEROTONIN METABOLISM AND CLINICAL RESPONSE TO COMBINED IMIPRAMINE AND AMITRIPTYLINE THERAPY IN DEPRESSION |
title_short | NOREPINEPHRINE AND SEROTONIN METABOLISM AND CLINICAL RESPONSE TO COMBINED IMIPRAMINE AND AMITRIPTYLINE THERAPY IN DEPRESSION |
title_sort | norepinephrine and serotonin metabolism and clinical response to combined imipramine and amitriptyline therapy in depression |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988307/ https://www.ncbi.nlm.nih.gov/pubmed/21927500 |
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