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Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein

Alterations in the metabolism of amyloid precursor protein (APP) are believed to play a central role in Alzheimer disease pathogenesis. Burgeoning data indicate that APP is proteolytically processed in endosomal-autophagic-lysosomal compartments. In this study, we used both in vivo and in vitro para...

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Detalles Bibliográficos
Autores principales:	Boland, Barry, Smith, David A., Mooney, Declan, Jung, Sonia S., Walsh, Dominic M., Platt, Frances M.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988347/ https://www.ncbi.nlm.nih.gov/pubmed/20864542 http://dx.doi.org/10.1074/jbc.M110.186411

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