The Novel PMCA2 Pump Mutation Tommy Impairs Cytosolic Calcium Clearance in Hair Cells and Links to Deafness in Mice

The mechanotransduction process in hair cells in the inner ear is associated with the influx of calcium from the endolymph. Calcium is exported back to the endolymph via the splice variant w/a of the PMCA2 of the stereocilia membrane. To further investigate the role of the pump, we have identified a...

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Detalles Bibliográficos
Autores principales: Bortolozzi, Mario, Brini, Marisa, Parkinson, Nick, Crispino, Giulia, Scimemi, Pietro, De Siati, Romolo Daniele, Di Leva, Francesca, Parker, Andrew, Ortolano, Saida, Arslan, Edoardo, Brown, Steve D., Carafoli, Ernesto, Mammano, Fabio
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988374/
https://www.ncbi.nlm.nih.gov/pubmed/20826782
http://dx.doi.org/10.1074/jbc.M110.170092

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