Cargando…
Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality?
Synthetic RNA-based regulatory systems are used to program higher-level biological functions that could be exploited, among many applications, for in vivo diagnostic and therapeutic applications. Chen and colleagues have recently reported a significant technological advance by producing an RNA modul...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988444/ https://www.ncbi.nlm.nih.gov/pubmed/20959026 http://dx.doi.org/10.1186/gm198 |
_version_ | 1782192251773911040 |
---|---|
author | Lee, Sang Kil Calin, George A |
author_facet | Lee, Sang Kil Calin, George A |
author_sort | Lee, Sang Kil |
collection | PubMed |
description | Synthetic RNA-based regulatory systems are used to program higher-level biological functions that could be exploited, among many applications, for in vivo diagnostic and therapeutic applications. Chen and colleagues have recently reported a significant technological advance by producing an RNA modular device based on a hammerhead ribozyme and successfully tested its ability to control the proliferation of mammalian T lymphocytes. Like all exciting research, this work raises a lot of significant questions. How quickly will such knowledge be translated into clinical practice? How efficient will this system be in human clinical trials involving adaptive T-cell therapy? We discuss the possible advantages of using such new technologies for specific therapeutic applications. |
format | Text |
id | pubmed-2988444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29884442011-10-15 Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? Lee, Sang Kil Calin, George A Genome Med Commentary Synthetic RNA-based regulatory systems are used to program higher-level biological functions that could be exploited, among many applications, for in vivo diagnostic and therapeutic applications. Chen and colleagues have recently reported a significant technological advance by producing an RNA modular device based on a hammerhead ribozyme and successfully tested its ability to control the proliferation of mammalian T lymphocytes. Like all exciting research, this work raises a lot of significant questions. How quickly will such knowledge be translated into clinical practice? How efficient will this system be in human clinical trials involving adaptive T-cell therapy? We discuss the possible advantages of using such new technologies for specific therapeutic applications. BioMed Central 2010-10-15 /pmc/articles/PMC2988444/ /pubmed/20959026 http://dx.doi.org/10.1186/gm198 Text en Copyright ©2010 BioMed Central Ltd |
spellingShingle | Commentary Lee, Sang Kil Calin, George A Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? |
title | Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? |
title_full | Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? |
title_fullStr | Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? |
title_full_unstemmed | Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? |
title_short | Genetic control of mammalian T-cell proliferation with a synthetic RNA regulatory system - illusion or reality? |
title_sort | genetic control of mammalian t-cell proliferation with a synthetic rna regulatory system - illusion or reality? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988444/ https://www.ncbi.nlm.nih.gov/pubmed/20959026 http://dx.doi.org/10.1186/gm198 |
work_keys_str_mv | AT leesangkil geneticcontrolofmammaliantcellproliferationwithasyntheticrnaregulatorysystemillusionorreality AT calingeorgea geneticcontrolofmammaliantcellproliferationwithasyntheticrnaregulatorysystemillusionorreality |