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The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain
BACKGROUND: Cellular RNA polymerases (RNAPs) are complex molecular machines that combine catalysis with concerted conformational changes in the active center. Previous work showed that kinking of a hinge region near the C-terminus of the Bridge Helix (BH-H(C)) plays a critical role in controlling th...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988716/ https://www.ncbi.nlm.nih.gov/pubmed/21034443 http://dx.doi.org/10.1186/1741-7007-8-134 |