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The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinical settings suggesting that the neuroinflammatory response after an ischemic stroke is not...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988764/ https://www.ncbi.nlm.nih.gov/pubmed/21040547 http://dx.doi.org/10.1186/1742-2094-7-74 |
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author | Ceulemans, An-Gaëlle Zgavc, Tine Kooijman, Ron Hachimi-Idrissi, Said Sarre, Sophie Michotte, Yvette |
author_facet | Ceulemans, An-Gaëlle Zgavc, Tine Kooijman, Ron Hachimi-Idrissi, Said Sarre, Sophie Michotte, Yvette |
author_sort | Ceulemans, An-Gaëlle |
collection | PubMed |
description | Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinical settings suggesting that the neuroinflammatory response after an ischemic stroke is not entirely detrimental. This review describes the different key players in neuroinflammation and their possible detrimental and protective effects in stroke. Because of its inhibitory influence on several pathways of the ischemic cascade, hypothermia has been introduced as a promising neuroprotective strategy. This review also discusses the influence of hypothermia on the neuroinflammatory response. We conclude that hypothermia exerts both stimulating and inhibiting effects on different aspects of neuroinflammation and hypothesize that these effects are key to neuroprotection. |
format | Text |
id | pubmed-2988764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29887642010-11-20 The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia Ceulemans, An-Gaëlle Zgavc, Tine Kooijman, Ron Hachimi-Idrissi, Said Sarre, Sophie Michotte, Yvette J Neuroinflammation Review Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinical settings suggesting that the neuroinflammatory response after an ischemic stroke is not entirely detrimental. This review describes the different key players in neuroinflammation and their possible detrimental and protective effects in stroke. Because of its inhibitory influence on several pathways of the ischemic cascade, hypothermia has been introduced as a promising neuroprotective strategy. This review also discusses the influence of hypothermia on the neuroinflammatory response. We conclude that hypothermia exerts both stimulating and inhibiting effects on different aspects of neuroinflammation and hypothesize that these effects are key to neuroprotection. BioMed Central 2010-11-01 /pmc/articles/PMC2988764/ /pubmed/21040547 http://dx.doi.org/10.1186/1742-2094-7-74 Text en Copyright ©2010 Ceulemans et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Ceulemans, An-Gaëlle Zgavc, Tine Kooijman, Ron Hachimi-Idrissi, Said Sarre, Sophie Michotte, Yvette The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia |
title | The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia |
title_full | The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia |
title_fullStr | The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia |
title_full_unstemmed | The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia |
title_short | The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia |
title_sort | dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988764/ https://www.ncbi.nlm.nih.gov/pubmed/21040547 http://dx.doi.org/10.1186/1742-2094-7-74 |
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