The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinical settings suggesting that the neuroinflammatory response after an ischemic stroke is not...

Descripción completa

Detalles Bibliográficos
Autores principales: Ceulemans, An-Gaëlle, Zgavc, Tine, Kooijman, Ron, Hachimi-Idrissi, Said, Sarre, Sophie, Michotte, Yvette
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988764/
https://www.ncbi.nlm.nih.gov/pubmed/21040547
http://dx.doi.org/10.1186/1742-2094-7-74
_version_ 1782192276677591040
author Ceulemans, An-Gaëlle
Zgavc, Tine
Kooijman, Ron
Hachimi-Idrissi, Said
Sarre, Sophie
Michotte, Yvette
author_facet Ceulemans, An-Gaëlle
Zgavc, Tine
Kooijman, Ron
Hachimi-Idrissi, Said
Sarre, Sophie
Michotte, Yvette
author_sort Ceulemans, An-Gaëlle
collection PubMed
description Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinical settings suggesting that the neuroinflammatory response after an ischemic stroke is not entirely detrimental. This review describes the different key players in neuroinflammation and their possible detrimental and protective effects in stroke. Because of its inhibitory influence on several pathways of the ischemic cascade, hypothermia has been introduced as a promising neuroprotective strategy. This review also discusses the influence of hypothermia on the neuroinflammatory response. We conclude that hypothermia exerts both stimulating and inhibiting effects on different aspects of neuroinflammation and hypothesize that these effects are key to neuroprotection.
format Text
id pubmed-2988764
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-29887642010-11-20 The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia Ceulemans, An-Gaëlle Zgavc, Tine Kooijman, Ron Hachimi-Idrissi, Said Sarre, Sophie Michotte, Yvette J Neuroinflammation Review Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinical settings suggesting that the neuroinflammatory response after an ischemic stroke is not entirely detrimental. This review describes the different key players in neuroinflammation and their possible detrimental and protective effects in stroke. Because of its inhibitory influence on several pathways of the ischemic cascade, hypothermia has been introduced as a promising neuroprotective strategy. This review also discusses the influence of hypothermia on the neuroinflammatory response. We conclude that hypothermia exerts both stimulating and inhibiting effects on different aspects of neuroinflammation and hypothesize that these effects are key to neuroprotection. BioMed Central 2010-11-01 /pmc/articles/PMC2988764/ /pubmed/21040547 http://dx.doi.org/10.1186/1742-2094-7-74 Text en Copyright ©2010 Ceulemans et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Ceulemans, An-Gaëlle
Zgavc, Tine
Kooijman, Ron
Hachimi-Idrissi, Said
Sarre, Sophie
Michotte, Yvette
The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
title The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
title_full The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
title_fullStr The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
title_full_unstemmed The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
title_short The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
title_sort dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988764/
https://www.ncbi.nlm.nih.gov/pubmed/21040547
http://dx.doi.org/10.1186/1742-2094-7-74
work_keys_str_mv AT ceulemansangaelle thedualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT zgavctine thedualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT kooijmanron thedualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT hachimiidrissisaid thedualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT sarresophie thedualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT michotteyvette thedualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT ceulemansangaelle dualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT zgavctine dualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT kooijmanron dualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT hachimiidrissisaid dualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT sarresophie dualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia
AT michotteyvette dualroleoftheneuroinflammatoryresponseafterischemicstrokemodulatoryeffectsofhypothermia

Ejemplares similares