Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats

BACKGROUND: Apolipoprotein E (apoE) is a major cholesterol transport protein found in association with brain amyloid from Alzheimer's disease (AD) patients and the ε4 allele of apoE is a genetic risk factor for AD. Previous studies have shown that apoE forms a stable complex with amyloid β (Aβ)...

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Detalles Bibliográficos
Autores principales: Suon, Sokreine, Zhao, Jie, Villarreal, Stephanie A, Anumula, Nikesh, Liu, Mali, Carangia, Linda M, Renger, John J, Zerbinatti, Celina V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988784/
https://www.ncbi.nlm.nih.gov/pubmed/21034469
http://dx.doi.org/10.1186/1750-1326-5-44

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