Gemcitabine Functions Epigenetically by Inhibiting Repair Mediated DNA Demethylation

Gemcitabine is a cytotoxic cytidine analog, which is widely used in anti-cancer therapy. One mechanism by which gemcitabine acts is by inhibiting nucleotide excision repair (NER). Recently NER was implicated in Gadd45 mediated DNA demethylation and epigenetic gene activation. Here we analyzed the ef...

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Detalles Bibliográficos
Autores principales: Schäfer, Andrea, Schomacher, Lars, Barreto, Guillermo, Döderlein, Gabi, Niehrs, Christof
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988820/
https://www.ncbi.nlm.nih.gov/pubmed/21124914
http://dx.doi.org/10.1371/journal.pone.0014060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988820/
https://www.ncbi.nlm.nih.gov/pubmed/21124914
http://dx.doi.org/10.1371/journal.pone.0014060

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