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Gemcitabine Functions Epigenetically by Inhibiting Repair Mediated DNA Demethylation
Gemcitabine is a cytotoxic cytidine analog, which is widely used in anti-cancer therapy. One mechanism by which gemcitabine acts is by inhibiting nucleotide excision repair (NER). Recently NER was implicated in Gadd45 mediated DNA demethylation and epigenetic gene activation. Here we analyzed the ef...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988820/ https://www.ncbi.nlm.nih.gov/pubmed/21124914 http://dx.doi.org/10.1371/journal.pone.0014060 |