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Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma

We describe a case of papillated Bowen disease (PBD), associated with a clear cell atypical fibroxanthoma (CCAFXA). The epidermal lesion showed a bowenoid papillomatous growth pattern with histologic features suggestive of infection by human papilloma virus (HPV). In the dermis a neoplasm made up by...

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Autores principales: Suárez-Vilela, Dimas, Izquierdo-García, Francisco, Domínguez-Iglesias, Francisco, Méndez-Álvarez, Jose Ramón
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988839/
https://www.ncbi.nlm.nih.gov/pubmed/21103191
http://dx.doi.org/10.1159/000314232
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author Suárez-Vilela, Dimas
Izquierdo-García, Francisco
Domínguez-Iglesias, Francisco
Méndez-Álvarez, Jose Ramón
author_facet Suárez-Vilela, Dimas
Izquierdo-García, Francisco
Domínguez-Iglesias, Francisco
Méndez-Álvarez, Jose Ramón
author_sort Suárez-Vilela, Dimas
collection PubMed
description We describe a case of papillated Bowen disease (PBD), associated with a clear cell atypical fibroxanthoma (CCAFXA). The epidermal lesion showed a bowenoid papillomatous growth pattern with histologic features suggestive of infection by human papilloma virus (HPV). In the dermis a neoplasm made up by spindled or polygonal cells with wide clear cytoplasm and moderate nuclear pleomorphism was found. Immunohistochemical characteristics of these two lesions were clearly different. The atypical cells of the intraepidermal proliferation were positive for AE1-AE3 anticytokeratin antibody, EMA, p16, p53 and p63. The dermal tumor was positive for vimentin, CD10, CD68, CD99, alpha-1-antitrypsin and c-kit. Histological features and immunohistochemical profile of the dermal tumor corresponded to a CCAFXA, a very uncommon neoplasm of which only 10 cases have been reported. In situ hybridization for numerous types of HPVs was negative in both lesions.
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spelling pubmed-29888392010-11-22 Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma Suárez-Vilela, Dimas Izquierdo-García, Francisco Domínguez-Iglesias, Francisco Méndez-Álvarez, Jose Ramón Case Rep Dermatol Published: May 2010 We describe a case of papillated Bowen disease (PBD), associated with a clear cell atypical fibroxanthoma (CCAFXA). The epidermal lesion showed a bowenoid papillomatous growth pattern with histologic features suggestive of infection by human papilloma virus (HPV). In the dermis a neoplasm made up by spindled or polygonal cells with wide clear cytoplasm and moderate nuclear pleomorphism was found. Immunohistochemical characteristics of these two lesions were clearly different. The atypical cells of the intraepidermal proliferation were positive for AE1-AE3 anticytokeratin antibody, EMA, p16, p53 and p63. The dermal tumor was positive for vimentin, CD10, CD68, CD99, alpha-1-antitrypsin and c-kit. Histological features and immunohistochemical profile of the dermal tumor corresponded to a CCAFXA, a very uncommon neoplasm of which only 10 cases have been reported. In situ hybridization for numerous types of HPVs was negative in both lesions. S. Karger AG 2010-05-07 /pmc/articles/PMC2988839/ /pubmed/21103191 http://dx.doi.org/10.1159/000314232 Text en Copyright © 2010 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published: May 2010
Suárez-Vilela, Dimas
Izquierdo-García, Francisco
Domínguez-Iglesias, Francisco
Méndez-Álvarez, Jose Ramón
Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma
title Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma
title_full Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma
title_fullStr Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma
title_full_unstemmed Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma
title_short Combined Papillated Bowen Disease and Clear Cell Atypical Fibroxanthoma
title_sort combined papillated bowen disease and clear cell atypical fibroxanthoma
topic Published: May 2010
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988839/
https://www.ncbi.nlm.nih.gov/pubmed/21103191
http://dx.doi.org/10.1159/000314232
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