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Robust Cardiomyocyte-Specific Gene Expression Following Systemic Injection of AAV: In Vivo Gene Delivery Follows a Poisson Distribution
Newly-isolated serotypes of AAV readily cross the endothelial barrier to provide efficient transgene delivery throughout the body. However, tissue-specific expression is preferred in most experimental studies and gene therapy protocols. Previous efforts to restrict gene expression to the myocardium...
Autores principales: | Prasad, Konkal-Matt R., Xu, Yaqin, Yang, Zequan, Acton, Scott T., French, Brent A |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988989/ https://www.ncbi.nlm.nih.gov/pubmed/20703310 http://dx.doi.org/10.1038/gt.2010.105 |
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