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Slipped upper femoral epiphysis with hemophilia A

A 13-year-old boy who had hemophilia A was reported with pain in the left thigh and hip on walking. He had no history of trauma. Severe hemophilia A is diagnosed with a Factor VIII level of <1 iu/dl. The presumptive diagnosis was that of a spontaneous bleed into the hip joint. Factor VIII mutatio...

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Detalles Bibliográficos
Autores principales: Iyer, Deepa, Brueton, Richard
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989130/
https://www.ncbi.nlm.nih.gov/pubmed/21139756
http://dx.doi.org/10.4103/0019-5413.33694
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author Iyer, Deepa
Brueton, Richard
author_facet Iyer, Deepa
Brueton, Richard
author_sort Iyer, Deepa
collection PubMed
description A 13-year-old boy who had hemophilia A was reported with pain in the left thigh and hip on walking. He had no history of trauma. Severe hemophilia A is diagnosed with a Factor VIII level of <1 iu/dl. The presumptive diagnosis was that of a spontaneous bleed into the hip joint. Factor VIII mutational analysis revealed a C to G substitution at nucleotide 6683 which results in a cystine change at codon 2194. However, the symptoms persisted and an X-ray demonstrated the presence of an acute on chronic slip of the upper femoral epiphysis. The patient was transferred to the center treating his hemophilia where the hip was pinned in situ under cover with Factor VIII. This case demonstrates the need to be aware of a possible traumatic diagnosis of hip pain in a hemophiliac child with a longstanding history of spontaneous bleeding into joints.
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spelling pubmed-29891302010-12-07 Slipped upper femoral epiphysis with hemophilia A Iyer, Deepa Brueton, Richard Indian J Orthop Case Report A 13-year-old boy who had hemophilia A was reported with pain in the left thigh and hip on walking. He had no history of trauma. Severe hemophilia A is diagnosed with a Factor VIII level of <1 iu/dl. The presumptive diagnosis was that of a spontaneous bleed into the hip joint. Factor VIII mutational analysis revealed a C to G substitution at nucleotide 6683 which results in a cystine change at codon 2194. However, the symptoms persisted and an X-ray demonstrated the presence of an acute on chronic slip of the upper femoral epiphysis. The patient was transferred to the center treating his hemophilia where the hip was pinned in situ under cover with Factor VIII. This case demonstrates the need to be aware of a possible traumatic diagnosis of hip pain in a hemophiliac child with a longstanding history of spontaneous bleeding into joints. Medknow Publications 2007 /pmc/articles/PMC2989130/ /pubmed/21139756 http://dx.doi.org/10.4103/0019-5413.33694 Text en © Indian Journal of Orthopaedics http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Iyer, Deepa
Brueton, Richard
Slipped upper femoral epiphysis with hemophilia A
title Slipped upper femoral epiphysis with hemophilia A
title_full Slipped upper femoral epiphysis with hemophilia A
title_fullStr Slipped upper femoral epiphysis with hemophilia A
title_full_unstemmed Slipped upper femoral epiphysis with hemophilia A
title_short Slipped upper femoral epiphysis with hemophilia A
title_sort slipped upper femoral epiphysis with hemophilia a
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989130/
https://www.ncbi.nlm.nih.gov/pubmed/21139756
http://dx.doi.org/10.4103/0019-5413.33694
work_keys_str_mv AT iyerdeepa slippedupperfemoralepiphysiswithhemophiliaa
AT bruetonrichard slippedupperfemoralepiphysiswithhemophiliaa