The dog as an animal model for DISH?

Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic disorder of the axial and peripheral skeleton in humans and has incidentally been described in dogs. The aims of this retrospective radiographic cohort study were to determine the prevalence of DISH in an outpatient population of skeletal...

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Autores principales: Kranenburg, H. C., Westerveld, L. A., Verlaan, J. J., Oner, F. C., Dhert, W. J. A., Voorhout, G., Hazewinkel, H. A. W., Meij, B. P.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989211/
https://www.ncbi.nlm.nih.gov/pubmed/20127259
http://dx.doi.org/10.1007/s00586-010-1280-6
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author Kranenburg, H. C.
Westerveld, L. A.
Verlaan, J. J.
Oner, F. C.
Dhert, W. J. A.
Voorhout, G.
Hazewinkel, H. A. W.
Meij, B. P.
author_facet Kranenburg, H. C.
Westerveld, L. A.
Verlaan, J. J.
Oner, F. C.
Dhert, W. J. A.
Voorhout, G.
Hazewinkel, H. A. W.
Meij, B. P.
author_sort Kranenburg, H. C.
collection PubMed
description Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic disorder of the axial and peripheral skeleton in humans and has incidentally been described in dogs. The aims of this retrospective radiographic cohort study were to determine the prevalence of DISH in an outpatient population of skeletally mature dogs and to investigate if dogs can be used as an animal model for DISH. The overall prevalence of canine DISH was 3.8% (78/2041). The prevalence of DISH increased with age and was more frequent in male dogs, similar to findings in human studies. In the Boxer breed the prevalence of DISH was 40.6% (28/69). Dog breeds represent closed gene pools with a high degree of familiar relationship and the high prevalence in the Boxer may be indicative of a genetic origin of DISH. It is concluded that the Boxer breed may serve as an animal model for DISH in humans.
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spelling pubmed-29892112010-12-28 The dog as an animal model for DISH? Kranenburg, H. C. Westerveld, L. A. Verlaan, J. J. Oner, F. C. Dhert, W. J. A. Voorhout, G. Hazewinkel, H. A. W. Meij, B. P. Eur Spine J Original Article Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic disorder of the axial and peripheral skeleton in humans and has incidentally been described in dogs. The aims of this retrospective radiographic cohort study were to determine the prevalence of DISH in an outpatient population of skeletally mature dogs and to investigate if dogs can be used as an animal model for DISH. The overall prevalence of canine DISH was 3.8% (78/2041). The prevalence of DISH increased with age and was more frequent in male dogs, similar to findings in human studies. In the Boxer breed the prevalence of DISH was 40.6% (28/69). Dog breeds represent closed gene pools with a high degree of familiar relationship and the high prevalence in the Boxer may be indicative of a genetic origin of DISH. It is concluded that the Boxer breed may serve as an animal model for DISH in humans. Springer-Verlag 2010-02-02 2010-08 /pmc/articles/PMC2989211/ /pubmed/20127259 http://dx.doi.org/10.1007/s00586-010-1280-6 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Kranenburg, H. C.
Westerveld, L. A.
Verlaan, J. J.
Oner, F. C.
Dhert, W. J. A.
Voorhout, G.
Hazewinkel, H. A. W.
Meij, B. P.
The dog as an animal model for DISH?
title The dog as an animal model for DISH?
title_full The dog as an animal model for DISH?
title_fullStr The dog as an animal model for DISH?
title_full_unstemmed The dog as an animal model for DISH?
title_short The dog as an animal model for DISH?
title_sort dog as an animal model for dish?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989211/
https://www.ncbi.nlm.nih.gov/pubmed/20127259
http://dx.doi.org/10.1007/s00586-010-1280-6
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