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Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

BACKGROUND: It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment. However, recent evidence suggests that tau tangles are not the entity responsible for...

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Detalles Bibliográficos
Autores principales:	O'Leary, John C, Li, Qingyou, Marinec, Paul, Blair, Laura J, Congdon, Erin E, Johnson, Amelia G, Jinwal, Umesh K, Koren, John, Jones, Jeffrey R, Kraft, Clara, Peters, Melinda, Abisambra, Jose F, Duff, Karen E, Weeber, Edwin J, Gestwicki, Jason E, Dickey, Chad A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989315/ https://www.ncbi.nlm.nih.gov/pubmed/21040568 http://dx.doi.org/10.1186/1750-1326-5-45

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