Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

MAPK and AKT pathways are frequently co-activated in melanoma through overexpression of receptor tyrosine kinases, mutations in their signaling surrogates, such as RAS and BRAF, or loss of negative regulators such as PTEN. Since RAS can be a positive upstream regulator of PI3-K, it has been proposed...

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Detalles Bibliográficos
Autores principales: Nogueira, Cristina, Kim, Kwan-Hyun, Sung, Hyeran, Paraiso, Kim, Dannenberg, Jan-Hermen, Bosenberg, Marcus, Chin, Lynda, Kim, Minjung
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989338/
https://www.ncbi.nlm.nih.gov/pubmed/20711233
http://dx.doi.org/10.1038/onc.2010.349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989338/
https://www.ncbi.nlm.nih.gov/pubmed/20711233
http://dx.doi.org/10.1038/onc.2010.349

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