Cargando…

Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort

PURPOSE: Why early puberty is associated with worse cardiovascular outcomes is unknown. The relationship between puberty and lipids is unclear. Our aim was to assess whether age at puberty was associated with triglyceride and total low-density lipoprotein and high-density lipoprotein cholesterol at...

Descripción completa

Detalles Bibliográficos
Autores principales: Pierce, Mary B., Kuh, Diana, Hardy, Rebecca
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989433/
https://www.ncbi.nlm.nih.gov/pubmed/20696407
http://dx.doi.org/10.1016/j.annepidem.2010.05.015
_version_ 1782192353207910400
author Pierce, Mary B.
Kuh, Diana
Hardy, Rebecca
author_facet Pierce, Mary B.
Kuh, Diana
Hardy, Rebecca
author_sort Pierce, Mary B.
collection PubMed
description PURPOSE: Why early puberty is associated with worse cardiovascular outcomes is unknown. The relationship between puberty and lipids is unclear. Our aim was to assess whether age at puberty was associated with triglyceride and total low-density lipoprotein and high-density lipoprotein cholesterol at age 53 years. METHODS: Participants in a national birth cohort were examined at 15 years, when pubertal stage for boys was assessed and age at menarche reported by the girls' mothers. At 53 years, 3035 were interviewed in their homes by research nurses, where blood was taken. RESULTS: There was a significant inverse relationship in women but not men between age at puberty (in years) and triglycerides (regression coefficient −0.2.9, 95% confidence interval −5.5, to −0.04, p = .02), age at puberty, and age at puberty and adult body mass index (BMI; p < .001). Relationships between puberty and lipids were completely explained by BMI or waist circumference at 53 years. CONCLUSIONS: In both sexes earlier maturation was associated with greater BMI and waist circumference in later life, which resulted in greater triglycerides and cholesterol in women. We suggest that intervention after puberty to help avoid obesity in early maturing women may improve their later cardiovascular health.
format Text
id pubmed-2989433
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-29894332010-12-07 Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort Pierce, Mary B. Kuh, Diana Hardy, Rebecca Ann Epidemiol Article PURPOSE: Why early puberty is associated with worse cardiovascular outcomes is unknown. The relationship between puberty and lipids is unclear. Our aim was to assess whether age at puberty was associated with triglyceride and total low-density lipoprotein and high-density lipoprotein cholesterol at age 53 years. METHODS: Participants in a national birth cohort were examined at 15 years, when pubertal stage for boys was assessed and age at menarche reported by the girls' mothers. At 53 years, 3035 were interviewed in their homes by research nurses, where blood was taken. RESULTS: There was a significant inverse relationship in women but not men between age at puberty (in years) and triglycerides (regression coefficient −0.2.9, 95% confidence interval −5.5, to −0.04, p = .02), age at puberty, and age at puberty and adult body mass index (BMI; p < .001). Relationships between puberty and lipids were completely explained by BMI or waist circumference at 53 years. CONCLUSIONS: In both sexes earlier maturation was associated with greater BMI and waist circumference in later life, which resulted in greater triglycerides and cholesterol in women. We suggest that intervention after puberty to help avoid obesity in early maturing women may improve their later cardiovascular health. Elsevier 2010-09 /pmc/articles/PMC2989433/ /pubmed/20696407 http://dx.doi.org/10.1016/j.annepidem.2010.05.015 Text en © 2010 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Pierce, Mary B.
Kuh, Diana
Hardy, Rebecca
Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort
title Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort
title_full Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort
title_fullStr Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort
title_full_unstemmed Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort
title_short Role of Lifetime Body Mass Index in the Association Between Age at Puberty and Adult Lipids: Findings From Men and Women in a British Birth Cohort
title_sort role of lifetime body mass index in the association between age at puberty and adult lipids: findings from men and women in a british birth cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989433/
https://www.ncbi.nlm.nih.gov/pubmed/20696407
http://dx.doi.org/10.1016/j.annepidem.2010.05.015
work_keys_str_mv AT piercemaryb roleoflifetimebodymassindexintheassociationbetweenageatpubertyandadultlipidsfindingsfrommenandwomeninabritishbirthcohort
AT kuhdiana roleoflifetimebodymassindexintheassociationbetweenageatpubertyandadultlipidsfindingsfrommenandwomeninabritishbirthcohort
AT hardyrebecca roleoflifetimebodymassindexintheassociationbetweenageatpubertyandadultlipidsfindingsfrommenandwomeninabritishbirthcohort