Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation

Cadherin23 has been proposed to form the upper part of the tip link, an interstereocilial link believed to control opening of transducer channels of sensory hair cells. However, we detect tip link-like links in mouse mutants with null alleles of Cdh23, suggesting the presence of other components tha...

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Detalles Bibliográficos
Autores principales: Rzadzinska, A.K., Steel, K.P.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2009
Materias:
Rapid Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989438/
https://www.ncbi.nlm.nih.gov/pubmed/18996172
http://dx.doi.org/10.1016/j.neuroscience.2008.10.012
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author Rzadzinska, A.K.
Steel, K.P.
author_facet Rzadzinska, A.K.
Steel, K.P.
author_sort Rzadzinska, A.K.
collection PubMed
description Cadherin23 has been proposed to form the upper part of the tip link, an interstereocilial link believed to control opening of transducer channels of sensory hair cells. However, we detect tip link-like links in mouse mutants with null alleles of Cdh23, suggesting the presence of other components that permit formation of a link between the tip of one stereocilium and the side of the adjacent taller stereocilium.
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spelling pubmed-29894382010-12-07 Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation Rzadzinska, A.K. Steel, K.P. Neuroscience Rapid Report Cadherin23 has been proposed to form the upper part of the tip link, an interstereocilial link believed to control opening of transducer channels of sensory hair cells. However, we detect tip link-like links in mouse mutants with null alleles of Cdh23, suggesting the presence of other components that permit formation of a link between the tip of one stereocilium and the side of the adjacent taller stereocilium. Elsevier Science 2009-01-23 /pmc/articles/PMC2989438/ /pubmed/18996172 http://dx.doi.org/10.1016/j.neuroscience.2008.10.012 Text en © 2009 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Rapid Report
Rzadzinska, A.K.
Steel, K.P.
Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation
title Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation
title_full Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation
title_fullStr Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation
title_full_unstemmed Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation
title_short Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip Link formation
title_sort presence of interstereocilial links in waltzer mutants suggests cdh23 is not essential for tip link formation
topic Rapid Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989438/
https://www.ncbi.nlm.nih.gov/pubmed/18996172
http://dx.doi.org/10.1016/j.neuroscience.2008.10.012
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