Cargando…

Fos expression in the brains of rats performing an attentional set-shifting task

Impairments in executive function and cognitive control are a common feature of neuropsychiatric and neurodegenerative disorders. A promising behavioral paradigm for elucidating the neural mechanisms of executive function is extradimensional/intradimensional (ED/ID) shifting, which places demands on...

Descripción completa

Detalles Bibliográficos
Autores principales: Burnham, K.E., Bannerman, D.M., Dawson, L.A., Southam, E., Sharp, T., Baxter, M.G.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989446/
https://www.ncbi.nlm.nih.gov/pubmed/20849932
http://dx.doi.org/10.1016/j.neuroscience.2010.09.008
_version_ 1782192356055842816
author Burnham, K.E.
Bannerman, D.M.
Dawson, L.A.
Southam, E.
Sharp, T.
Baxter, M.G.
author_facet Burnham, K.E.
Bannerman, D.M.
Dawson, L.A.
Southam, E.
Sharp, T.
Baxter, M.G.
author_sort Burnham, K.E.
collection PubMed
description Impairments in executive function and cognitive control are a common feature of neuropsychiatric and neurodegenerative disorders. A promising behavioral paradigm for elucidating the neural mechanisms of executive function is extradimensional/intradimensional (ED/ID) shifting, which places demands on executive function by requiring the adjustment of behavioral responses based on affective or attentional information. To augment the understanding of the brain systems required for these aspects of executive function, we examined the induction of Fos protein in rats tested in the ED/ID paradigm. We found increased Fos-like immunoreactivity (Fos-LI) in several cortical areas, including medial and orbital frontal cortex (OFC), in rats performing affective or attentional shifts relative to rats performing control discriminations. However, increased Fos-LI was also present in rats that performed a yoked number of additional control discrimination trials, without affective or attentional shifting. These observations suggest that cortical networks required for affective and attentional shifting are also activated during comparable discrimination tasks that do not require shifting, consistent with a role for these networks in monitoring ongoing behavior even in situations in which adaptation to changing behavioral demands is not required.
format Text
id pubmed-2989446
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Elsevier Science
record_format MEDLINE/PubMed
spelling pubmed-29894462010-12-07 Fos expression in the brains of rats performing an attentional set-shifting task Burnham, K.E. Bannerman, D.M. Dawson, L.A. Southam, E. Sharp, T. Baxter, M.G. Neuroscience Cognitive, Behavioral, and Systems Neuroscience Impairments in executive function and cognitive control are a common feature of neuropsychiatric and neurodegenerative disorders. A promising behavioral paradigm for elucidating the neural mechanisms of executive function is extradimensional/intradimensional (ED/ID) shifting, which places demands on executive function by requiring the adjustment of behavioral responses based on affective or attentional information. To augment the understanding of the brain systems required for these aspects of executive function, we examined the induction of Fos protein in rats tested in the ED/ID paradigm. We found increased Fos-like immunoreactivity (Fos-LI) in several cortical areas, including medial and orbital frontal cortex (OFC), in rats performing affective or attentional shifts relative to rats performing control discriminations. However, increased Fos-LI was also present in rats that performed a yoked number of additional control discrimination trials, without affective or attentional shifting. These observations suggest that cortical networks required for affective and attentional shifting are also activated during comparable discrimination tasks that do not require shifting, consistent with a role for these networks in monitoring ongoing behavior even in situations in which adaptation to changing behavioral demands is not required. Elsevier Science 2010-12-01 /pmc/articles/PMC2989446/ /pubmed/20849932 http://dx.doi.org/10.1016/j.neuroscience.2010.09.008 Text en © 2010 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Cognitive, Behavioral, and Systems Neuroscience
Burnham, K.E.
Bannerman, D.M.
Dawson, L.A.
Southam, E.
Sharp, T.
Baxter, M.G.
Fos expression in the brains of rats performing an attentional set-shifting task
title Fos expression in the brains of rats performing an attentional set-shifting task
title_full Fos expression in the brains of rats performing an attentional set-shifting task
title_fullStr Fos expression in the brains of rats performing an attentional set-shifting task
title_full_unstemmed Fos expression in the brains of rats performing an attentional set-shifting task
title_short Fos expression in the brains of rats performing an attentional set-shifting task
title_sort fos expression in the brains of rats performing an attentional set-shifting task
topic Cognitive, Behavioral, and Systems Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989446/
https://www.ncbi.nlm.nih.gov/pubmed/20849932
http://dx.doi.org/10.1016/j.neuroscience.2010.09.008
work_keys_str_mv AT burnhamke fosexpressioninthebrainsofratsperforminganattentionalsetshiftingtask
AT bannermandm fosexpressioninthebrainsofratsperforminganattentionalsetshiftingtask
AT dawsonla fosexpressioninthebrainsofratsperforminganattentionalsetshiftingtask
AT southame fosexpressioninthebrainsofratsperforminganattentionalsetshiftingtask
AT sharpt fosexpressioninthebrainsofratsperforminganattentionalsetshiftingtask
AT baxtermg fosexpressioninthebrainsofratsperforminganattentionalsetshiftingtask