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Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma
Autoantibodies (AAbs) to tumor-associated antigens (TAAs) have been identified in the circulation of patients with cancer. This paper will focus on recent knowledge related to circulating AAbs to TAAs in breast carcinoma. So far, the following TAAs have been identified to elicit circulating AAbs in...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989457/ https://www.ncbi.nlm.nih.gov/pubmed/21113302 http://dx.doi.org/10.1155/2010/264926 |
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author | Piura, Ettie Piura, Benjamin |
author_facet | Piura, Ettie Piura, Benjamin |
author_sort | Piura, Ettie |
collection | PubMed |
description | Autoantibodies (AAbs) to tumor-associated antigens (TAAs) have been identified in the circulation of patients with cancer. This paper will focus on recent knowledge related to circulating AAbs to TAAs in breast carcinoma. So far, the following TAAs have been identified to elicit circulating AAbs in breast carcinoma: p53, MUC-1, heat shock proteins (HSP-27, HSP-60, and HSP-90), HER2/neu/c-erb B2, GIPC-1, c-myc, c-myb, cancer-testis antigens (NY-ESO-1), BRCA1, BRCA2, endostatin, lipophilin B, cyclin B1, cyclin D1, fibulin, insulin-like growth factor binding protein 2 (IGFBP-2), topoisomerase II alpha (TOPO2α), and cathepsin D. Measurement of serum AAbs to one specific TAA only is of little value for screening and early diagnosis of breast carcinoma; however, assessment of AAbs to a panel of TAAs may have promising diagnostic potential. |
format | Text |
id | pubmed-2989457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29894572010-11-26 Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma Piura, Ettie Piura, Benjamin J Oncol Review Article Autoantibodies (AAbs) to tumor-associated antigens (TAAs) have been identified in the circulation of patients with cancer. This paper will focus on recent knowledge related to circulating AAbs to TAAs in breast carcinoma. So far, the following TAAs have been identified to elicit circulating AAbs in breast carcinoma: p53, MUC-1, heat shock proteins (HSP-27, HSP-60, and HSP-90), HER2/neu/c-erb B2, GIPC-1, c-myc, c-myb, cancer-testis antigens (NY-ESO-1), BRCA1, BRCA2, endostatin, lipophilin B, cyclin B1, cyclin D1, fibulin, insulin-like growth factor binding protein 2 (IGFBP-2), topoisomerase II alpha (TOPO2α), and cathepsin D. Measurement of serum AAbs to one specific TAA only is of little value for screening and early diagnosis of breast carcinoma; however, assessment of AAbs to a panel of TAAs may have promising diagnostic potential. Hindawi Publishing Corporation 2010 2010-11-21 /pmc/articles/PMC2989457/ /pubmed/21113302 http://dx.doi.org/10.1155/2010/264926 Text en Copyright © 2010 E. Piura and B. Piura. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Piura, Ettie Piura, Benjamin Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma |
title | Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma |
title_full | Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma |
title_fullStr | Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma |
title_full_unstemmed | Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma |
title_short | Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma |
title_sort | autoantibodies to tumor-associated antigens in breast carcinoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989457/ https://www.ncbi.nlm.nih.gov/pubmed/21113302 http://dx.doi.org/10.1155/2010/264926 |
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