Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells

T cell activation is invariably associated with virus infections, but activation of T cells is also noted, for example, in patients with persistent bacterial infections with intracellular pathogens or localised bacterial biofilms. The latter is characterised by a destructive inflammatory process. Ma...

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Autores principales: Kotsougiani, Dimitra, Pioch, Marco, Prior, Birgit, Heppert, Volkmar, Hänsch, G. Maria, Wagner, Christof
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989653/
https://www.ncbi.nlm.nih.gov/pubmed/21151520
http://dx.doi.org/10.4061/2010/526740
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author Kotsougiani, Dimitra
Pioch, Marco
Prior, Birgit
Heppert, Volkmar
Hänsch, G. Maria
Wagner, Christof
author_facet Kotsougiani, Dimitra
Pioch, Marco
Prior, Birgit
Heppert, Volkmar
Hänsch, G. Maria
Wagner, Christof
author_sort Kotsougiani, Dimitra
collection PubMed
description T cell activation is invariably associated with virus infections, but activation of T cells is also noted, for example, in patients with persistent bacterial infections with intracellular pathogens or localised bacterial biofilms. The latter is characterised by a destructive inflammatory process. Massive infiltration of leukocytes, predominantly of polymorphonuclear neutrophils (PMNs) and of T lymphocytes, is seen. While PMN influx into sites of bacterial infection is in line with their role as “first-line defence” a role of T cells in bacterial infection has not yet been delineated. We now found evidence for activation and expansion of peripheral blood T cells and an upregulation of Toll-like receptors 1, 2, and 4 on small portions of T cells. T cells recovered from the infected site were terminally differentiated and produced interferon gamma, a cytokine known to enhance functions of phagocytic cells, leading to the conclusion that infiltrated T cells support the local immuner defence.
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spelling pubmed-29896532010-12-13 Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells Kotsougiani, Dimitra Pioch, Marco Prior, Birgit Heppert, Volkmar Hänsch, G. Maria Wagner, Christof Int J Inflam Clinical Study T cell activation is invariably associated with virus infections, but activation of T cells is also noted, for example, in patients with persistent bacterial infections with intracellular pathogens or localised bacterial biofilms. The latter is characterised by a destructive inflammatory process. Massive infiltration of leukocytes, predominantly of polymorphonuclear neutrophils (PMNs) and of T lymphocytes, is seen. While PMN influx into sites of bacterial infection is in line with their role as “first-line defence” a role of T cells in bacterial infection has not yet been delineated. We now found evidence for activation and expansion of peripheral blood T cells and an upregulation of Toll-like receptors 1, 2, and 4 on small portions of T cells. T cells recovered from the infected site were terminally differentiated and produced interferon gamma, a cytokine known to enhance functions of phagocytic cells, leading to the conclusion that infiltrated T cells support the local immuner defence. SAGE-Hindawi Access to Research 2010-04-22 /pmc/articles/PMC2989653/ /pubmed/21151520 http://dx.doi.org/10.4061/2010/526740 Text en Copyright © 2010 Dimitra Kotsougiani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Kotsougiani, Dimitra
Pioch, Marco
Prior, Birgit
Heppert, Volkmar
Hänsch, G. Maria
Wagner, Christof
Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells
title Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells
title_full Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells
title_fullStr Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells
title_full_unstemmed Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells
title_short Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells
title_sort activation of t lymphocytes in response to persistent bacterial infection: induction of cd11b and of toll-like receptors on t cells
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989653/
https://www.ncbi.nlm.nih.gov/pubmed/21151520
http://dx.doi.org/10.4061/2010/526740
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