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N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment
A growing body of clinical and epidemiological evidence suggests that low dietary intake and/or tissue levels of n-3 (omega-3) polyunsaturated fatty acids (PUFAs) are associated with postpartum depression. Low tissue levels of n-3 PUFAs, particularly docosahexaenoic acid (DHA), are reported in patie...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989696/ https://www.ncbi.nlm.nih.gov/pubmed/21151517 http://dx.doi.org/10.1155/2011/467349 |
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author | Levant, Beth |
author_facet | Levant, Beth |
author_sort | Levant, Beth |
collection | PubMed |
description | A growing body of clinical and epidemiological evidence suggests that low dietary intake and/or tissue levels of n-3 (omega-3) polyunsaturated fatty acids (PUFAs) are associated with postpartum depression. Low tissue levels of n-3 PUFAs, particularly docosahexaenoic acid (DHA), are reported in patients with either postpartum or nonpuerperal depression. Moreover, the physiological demands of pregnancy and lactation put childbearing women at particular risk of experiencing a loss of DHA from tissues including the brain, especially in individuals with inadequate dietary n-3 PUFA intake or suboptimal metabolic capabilities. Animal studies indicate that decreased brain DHA in postpartum females leads to several depression-associated neurobiological changes including decreased hippocampal brain-derived neurotrophic factor and augmented hypothalamic-pituitary-adrenal responses to stress. Taken together, these findings support a role for decreased brain n-3 PUFAs in the multifactorial etiology of depression, particularly postpartum depression. These findings, and their implications for research and clinical practice, are discussed. |
format | Text |
id | pubmed-2989696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29896962010-12-13 N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment Levant, Beth Depress Res Treat Review Article A growing body of clinical and epidemiological evidence suggests that low dietary intake and/or tissue levels of n-3 (omega-3) polyunsaturated fatty acids (PUFAs) are associated with postpartum depression. Low tissue levels of n-3 PUFAs, particularly docosahexaenoic acid (DHA), are reported in patients with either postpartum or nonpuerperal depression. Moreover, the physiological demands of pregnancy and lactation put childbearing women at particular risk of experiencing a loss of DHA from tissues including the brain, especially in individuals with inadequate dietary n-3 PUFA intake or suboptimal metabolic capabilities. Animal studies indicate that decreased brain DHA in postpartum females leads to several depression-associated neurobiological changes including decreased hippocampal brain-derived neurotrophic factor and augmented hypothalamic-pituitary-adrenal responses to stress. Taken together, these findings support a role for decreased brain n-3 PUFAs in the multifactorial etiology of depression, particularly postpartum depression. These findings, and their implications for research and clinical practice, are discussed. Hindawi Publishing Corporation 2011 2010-10-27 /pmc/articles/PMC2989696/ /pubmed/21151517 http://dx.doi.org/10.1155/2011/467349 Text en Copyright © 2011 Beth Levant. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Levant, Beth N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment |
title | N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment |
title_full | N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment |
title_fullStr | N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment |
title_full_unstemmed | N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment |
title_short | N-3 (Omega-3) Fatty Acids in Postpartum Depression: Implications for Prevention and Treatment |
title_sort | n-3 (omega-3) fatty acids in postpartum depression: implications for prevention and treatment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989696/ https://www.ncbi.nlm.nih.gov/pubmed/21151517 http://dx.doi.org/10.1155/2011/467349 |
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