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Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis

C-reactive protein (CRP), an acute-phase reactant, has been identified as a saliva-based biomarker of inflammation. The objective of the study was to estimate and compare salivary CRP levels in Hashimoto's thyroiditis (HT) and Subacute thyroiditis (SAT). The study included 30 HT patients who pr...

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Autores principales: Rao, Nivedita L., Shetty, Sukanya, Upadhyaya, Krishnaraj, R. M, Prasad, Lobo, Eric C., Kedilaya, H. P., Prasad, Ganesh
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989710/
https://www.ncbi.nlm.nih.gov/pubmed/21151525
http://dx.doi.org/10.4061/2010/514659
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author Rao, Nivedita L.
Shetty, Sukanya
Upadhyaya, Krishnaraj
R. M, Prasad
Lobo, Eric C.
Kedilaya, H. P.
Prasad, Ganesh
author_facet Rao, Nivedita L.
Shetty, Sukanya
Upadhyaya, Krishnaraj
R. M, Prasad
Lobo, Eric C.
Kedilaya, H. P.
Prasad, Ganesh
author_sort Rao, Nivedita L.
collection PubMed
description C-reactive protein (CRP), an acute-phase reactant, has been identified as a saliva-based biomarker of inflammation. The objective of the study was to estimate and compare salivary CRP levels in Hashimoto's thyroiditis (HT) and Subacute thyroiditis (SAT). The study included 30 HT patients who presented with clinical features of hypothyroidism, 15 SAT patients who presented with clinical features of hyperthyroidism, and 20 healthy age- and sex-matched euthyroid controls. CRP levels in saliva were estimated using an Enzyme-Linked Immunosorbent Assay method with enhanced sensitivity. In HT, the mean salivary CRP levels did not differ significantly from controls. SAT patients had significantly elevated salivary CRP levels compared to HT patients and controls. The rise in salivary CRP levels in SAT patients conceivably reflects the presence of an inflammatory process. Saliva CRP levels appear to serve as inflammatory markers in SAT patients and may aid their clinical evaluation.
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spelling pubmed-29897102010-12-13 Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis Rao, Nivedita L. Shetty, Sukanya Upadhyaya, Krishnaraj R. M, Prasad Lobo, Eric C. Kedilaya, H. P. Prasad, Ganesh Int J Inflam Research Article C-reactive protein (CRP), an acute-phase reactant, has been identified as a saliva-based biomarker of inflammation. The objective of the study was to estimate and compare salivary CRP levels in Hashimoto's thyroiditis (HT) and Subacute thyroiditis (SAT). The study included 30 HT patients who presented with clinical features of hypothyroidism, 15 SAT patients who presented with clinical features of hyperthyroidism, and 20 healthy age- and sex-matched euthyroid controls. CRP levels in saliva were estimated using an Enzyme-Linked Immunosorbent Assay method with enhanced sensitivity. In HT, the mean salivary CRP levels did not differ significantly from controls. SAT patients had significantly elevated salivary CRP levels compared to HT patients and controls. The rise in salivary CRP levels in SAT patients conceivably reflects the presence of an inflammatory process. Saliva CRP levels appear to serve as inflammatory markers in SAT patients and may aid their clinical evaluation. SAGE-Hindawi Access to Research 2010-09-14 /pmc/articles/PMC2989710/ /pubmed/21151525 http://dx.doi.org/10.4061/2010/514659 Text en Copyright © 2010 Nivedita L. Rao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rao, Nivedita L.
Shetty, Sukanya
Upadhyaya, Krishnaraj
R. M, Prasad
Lobo, Eric C.
Kedilaya, H. P.
Prasad, Ganesh
Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis
title Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis
title_full Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis
title_fullStr Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis
title_full_unstemmed Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis
title_short Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis
title_sort salivary c-reactive protein in hashimoto's thyroiditis and subacute thyroiditis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989710/
https://www.ncbi.nlm.nih.gov/pubmed/21151525
http://dx.doi.org/10.4061/2010/514659
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