Cargando…
Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age
There are few pathologic descriptions of fatal coronary artery disease in the young. The morphologic characteristics of sudden coronary deaths in 47 hearts from patients younger than 40 years were studied. Numbers of plaques with necrotic cores were quantitated in each heart. Compared to 194 sudden...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989747/ https://www.ncbi.nlm.nih.gov/pubmed/21151510 http://dx.doi.org/10.4061/2010/628247 |
_version_ | 1782192388703256576 |
---|---|
author | Tavora, Fabio Li, Ling Ripple, Mary Fowler, David Burke, Allen |
author_facet | Tavora, Fabio Li, Ling Ripple, Mary Fowler, David Burke, Allen |
author_sort | Tavora, Fabio |
collection | PubMed |
description | There are few pathologic descriptions of fatal coronary artery disease in the young. The morphologic characteristics of sudden coronary deaths in 47 hearts from patients younger than 40 years were studied. Numbers of plaques with necrotic cores were quantitated in each heart. Compared to 194 sudden coronary deaths >40 years, heart weight was lower, acute plaque erosions more frequent, and extent of disease less in the ≤40 years group. Plaque burden was less in hearts with erosions, and healed infarcts more common in hearts with stable plaque. The numbers of fibroatheromas increased with age until the 6th decade (P < .0001) as well as the proportion of total plaques that were atheromatous. Plaques in younger patients have fewer lipid-rich cores. Most thrombi show areas of organization, with layering frequent in erosions, suggesting a possible method of plaque enlargement in the absence of necrotic core formation. |
format | Text |
id | pubmed-2989747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-29897472010-12-13 Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age Tavora, Fabio Li, Ling Ripple, Mary Fowler, David Burke, Allen Patholog Res Int Research Article There are few pathologic descriptions of fatal coronary artery disease in the young. The morphologic characteristics of sudden coronary deaths in 47 hearts from patients younger than 40 years were studied. Numbers of plaques with necrotic cores were quantitated in each heart. Compared to 194 sudden coronary deaths >40 years, heart weight was lower, acute plaque erosions more frequent, and extent of disease less in the ≤40 years group. Plaque burden was less in hearts with erosions, and healed infarcts more common in hearts with stable plaque. The numbers of fibroatheromas increased with age until the 6th decade (P < .0001) as well as the proportion of total plaques that were atheromatous. Plaques in younger patients have fewer lipid-rich cores. Most thrombi show areas of organization, with layering frequent in erosions, suggesting a possible method of plaque enlargement in the absence of necrotic core formation. SAGE-Hindawi Access to Research 2009-11-05 /pmc/articles/PMC2989747/ /pubmed/21151510 http://dx.doi.org/10.4061/2010/628247 Text en Copyright © 2010 Fabio Tavora et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tavora, Fabio Li, Ling Ripple, Mary Fowler, David Burke, Allen Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age |
title | Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age |
title_full | Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age |
title_fullStr | Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age |
title_full_unstemmed | Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age |
title_short | Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age |
title_sort | morphologic characteristic of coronary artery disease, with emphasis on thromboses, in patients younger than 40 years of age |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989747/ https://www.ncbi.nlm.nih.gov/pubmed/21151510 http://dx.doi.org/10.4061/2010/628247 |
work_keys_str_mv | AT tavorafabio morphologiccharacteristicofcoronaryarterydiseasewithemphasisonthrombosesinpatientsyoungerthan40yearsofage AT liling morphologiccharacteristicofcoronaryarterydiseasewithemphasisonthrombosesinpatientsyoungerthan40yearsofage AT ripplemary morphologiccharacteristicofcoronaryarterydiseasewithemphasisonthrombosesinpatientsyoungerthan40yearsofage AT fowlerdavid morphologiccharacteristicofcoronaryarterydiseasewithemphasisonthrombosesinpatientsyoungerthan40yearsofage AT burkeallen morphologiccharacteristicofcoronaryarterydiseasewithemphasisonthrombosesinpatientsyoungerthan40yearsofage |