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Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age

There are few pathologic descriptions of fatal coronary artery disease in the young. The morphologic characteristics of sudden coronary deaths in 47 hearts from patients younger than 40 years were studied. Numbers of plaques with necrotic cores were quantitated in each heart. Compared to 194 sudden...

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Autores principales: Tavora, Fabio, Li, Ling, Ripple, Mary, Fowler, David, Burke, Allen
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989747/
https://www.ncbi.nlm.nih.gov/pubmed/21151510
http://dx.doi.org/10.4061/2010/628247
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author Tavora, Fabio
Li, Ling
Ripple, Mary
Fowler, David
Burke, Allen
author_facet Tavora, Fabio
Li, Ling
Ripple, Mary
Fowler, David
Burke, Allen
author_sort Tavora, Fabio
collection PubMed
description There are few pathologic descriptions of fatal coronary artery disease in the young. The morphologic characteristics of sudden coronary deaths in 47 hearts from patients younger than 40 years were studied. Numbers of plaques with necrotic cores were quantitated in each heart. Compared to 194 sudden coronary deaths >40 years, heart weight was lower, acute plaque erosions more frequent, and extent of disease less in the ≤40 years group. Plaque burden was less in hearts with erosions, and healed infarcts more common in hearts with stable plaque. The numbers of fibroatheromas increased with age until the 6th decade (P < .0001) as well as the proportion of total plaques that were atheromatous. Plaques in younger patients have fewer lipid-rich cores. Most thrombi show areas of organization, with layering frequent in erosions, suggesting a possible method of plaque enlargement in the absence of necrotic core formation.
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spelling pubmed-29897472010-12-13 Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age Tavora, Fabio Li, Ling Ripple, Mary Fowler, David Burke, Allen Patholog Res Int Research Article There are few pathologic descriptions of fatal coronary artery disease in the young. The morphologic characteristics of sudden coronary deaths in 47 hearts from patients younger than 40 years were studied. Numbers of plaques with necrotic cores were quantitated in each heart. Compared to 194 sudden coronary deaths >40 years, heart weight was lower, acute plaque erosions more frequent, and extent of disease less in the ≤40 years group. Plaque burden was less in hearts with erosions, and healed infarcts more common in hearts with stable plaque. The numbers of fibroatheromas increased with age until the 6th decade (P < .0001) as well as the proportion of total plaques that were atheromatous. Plaques in younger patients have fewer lipid-rich cores. Most thrombi show areas of organization, with layering frequent in erosions, suggesting a possible method of plaque enlargement in the absence of necrotic core formation. SAGE-Hindawi Access to Research 2009-11-05 /pmc/articles/PMC2989747/ /pubmed/21151510 http://dx.doi.org/10.4061/2010/628247 Text en Copyright © 2010 Fabio Tavora et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tavora, Fabio
Li, Ling
Ripple, Mary
Fowler, David
Burke, Allen
Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age
title Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age
title_full Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age
title_fullStr Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age
title_full_unstemmed Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age
title_short Morphologic Characteristic of Coronary Artery Disease, with Emphasis on Thromboses, in Patients Younger Than 40 Years of Age
title_sort morphologic characteristic of coronary artery disease, with emphasis on thromboses, in patients younger than 40 years of age
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989747/
https://www.ncbi.nlm.nih.gov/pubmed/21151510
http://dx.doi.org/10.4061/2010/628247
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