Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia

Gain of chromosome 8 is the most common chromosomal gain in human acute myeloid leukemia (AML). It has been hypothesized that gain of the MYC protooncogene is of central importance in trisomy 8, but the experimental data to support this are limited and controversial. In a mouse model of promyelocyti...

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Detalles Bibliográficos
Autores principales: Jones, Letetia, Wei, Guangwei, Sevcikova, Sabina, Phan, Vernon, Jain, Sachi, Shieh, Angell, Wong, Jasmine C. Y., Li, Min, Dubansky, Joshua, Maunakea, Mei Lin, Ochoa, Rachel, Zhu, George, Tennant, Thelma R., Shannon, Kevin M., Lowe, Scott W., Le Beau, Michelle M., Kogan, Scott C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989761/
https://www.ncbi.nlm.nih.gov/pubmed/21059853
http://dx.doi.org/10.1084/jem.20091071

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