Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation

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In myeloid dendritic cells (mDCs), TLR3 is expressed in the endosomal membrane and interacts with the adaptor toll/interleukin 1 receptor homology domain–containing adaptor molecule 1 (TICAM-1; TRIF). TICAM-1 signals culminate in interferon (IFN) regulatory factor (IRF) 3 activation. Co-culture of m...

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Detalles Bibliográficos
Autores principales: Ebihara, Takashi, Azuma, Masahiro, Oshiumi, Hiroyuki, Kasamatsu, Jun, Iwabuchi, Kazuya, Matsumoto, Kenji, Saito, Hirohisa, Taniguchi, Tadatsugu, Matsumoto, Misako, Seya, Tsukasa
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989763/
https://www.ncbi.nlm.nih.gov/pubmed/21059856
http://dx.doi.org/10.1084/jem.20091573
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