Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90

Activation-induced deaminase (AID) is the mutator enzyme that initiates somatic hypermutation and isotype switching of the antibody genes in B lymphocytes. Undesired byproducts of AID function are oncogenic mutations. AID expression levels seem to correlate with the extent of its physiological and p...

Descripción completa

Detalles Bibliográficos
Autores principales: Orthwein, Alexandre, Patenaude, Anne-Marie, Affar, El Bachir, Lamarre, Alain, Young, Jason C., Di Noia, Javier M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989769/
https://www.ncbi.nlm.nih.gov/pubmed/21041454
http://dx.doi.org/10.1084/jem.20101321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989769/
https://www.ncbi.nlm.nih.gov/pubmed/21041454
http://dx.doi.org/10.1084/jem.20101321

Ejemplares similares