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Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90

Activation-induced deaminase (AID) is the mutator enzyme that initiates somatic hypermutation and isotype switching of the antibody genes in B lymphocytes. Undesired byproducts of AID function are oncogenic mutations. AID expression levels seem to correlate with the extent of its physiological and p...

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Detalles Bibliográficos
Autores principales:	Orthwein, Alexandre, Patenaude, Anne-Marie, Affar, El Bachir, Lamarre, Alain, Young, Jason C., Di Noia, Javier M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989769/ https://www.ncbi.nlm.nih.gov/pubmed/21041454 http://dx.doi.org/10.1084/jem.20101321

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