Mouse CD8α(+) DCs and human BDCA3(+) DCs are major producers of IFN-λ in response to poly IC

Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. IFN-λs (also termed IL-28/29) are potent immunomodulatory and antiviral cytokines. We demonstrate that poly IC injection in vivo induces large amounts of IFN-λ, which depended on hematopoietic cells a...

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Detalles Bibliográficos
Autores principales: Lauterbach, Henning, Bathke, Barbara, Gilles, Stefanie, Traidl-Hoffmann, Claudia, Luber, Christian A., Fejer, György, Freudenberg, Marina A., Davey, Gayle M., Vremec, David, Kallies, Axel, Wu, Li, Shortman, Ken, Chaplin, Paul, Suter, Mark, O’Keeffe, Meredith, Hochrein, Hubertus
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989774/
https://www.ncbi.nlm.nih.gov/pubmed/20975040
http://dx.doi.org/10.1084/jem.20092720

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