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Esophageal Cancer in Young People: A Case Series of 109 Cases and Review of the Literature

Certain geographically distinct areas of the world have very high rates of esophageal cancer (EC). Previous studies have identified western Kenya as a high risk area for EC with an unusual percentage of cases in subjects 30 years of age or younger. To better understand EC in these young patients, we...

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Autores principales: Dawsey, Sonja P., Tonui, Stanley, Parker, Robert K., Fitzwater, John W., Dawsey, Sanford M., White, Russell E., Abnet, Christian C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989919/
https://www.ncbi.nlm.nih.gov/pubmed/21124934
http://dx.doi.org/10.1371/journal.pone.0014080
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author Dawsey, Sonja P.
Tonui, Stanley
Parker, Robert K.
Fitzwater, John W.
Dawsey, Sanford M.
White, Russell E.
Abnet, Christian C.
author_facet Dawsey, Sonja P.
Tonui, Stanley
Parker, Robert K.
Fitzwater, John W.
Dawsey, Sanford M.
White, Russell E.
Abnet, Christian C.
author_sort Dawsey, Sonja P.
collection PubMed
description Certain geographically distinct areas of the world have very high rates of esophageal cancer (EC). Previous studies have identified western Kenya as a high risk area for EC with an unusual percentage of cases in subjects 30 years of age or younger. To better understand EC in these young patients, we abstracted available data on all 109 young patients diagnosed with EC at Tenwek Hospital, Bomet District, Kenya from January 1996 through June 2009, including age at diagnosis, sex, ethnicity, tumor histology, residence location, and medical interventions. We also attempted to contact all patients or a family member and obtained information on ethnicity, tobacco and alcohol use, family history of cancer, and survival. Sixty (55%) representatives of the 109 young patients were successfully interviewed. The median survival time of these 60 patients was 6.4 months, the most common tumor histology was esophageal squamous cell carcinoma (ESCC) (98%), the M:F ratio was 1.4∶1, and only a few subjects used tobacco (15%) or alcohol (15%). Seventy-nine percent reported a family history of cancer and 43% reported having a family history of EC. In summary, this case series describes the largest number of young EC patients reported to date, and it highlights the uniqueness of the EC experience in western Kenya.
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spelling pubmed-29899192010-12-01 Esophageal Cancer in Young People: A Case Series of 109 Cases and Review of the Literature Dawsey, Sonja P. Tonui, Stanley Parker, Robert K. Fitzwater, John W. Dawsey, Sanford M. White, Russell E. Abnet, Christian C. PLoS One Research Article Certain geographically distinct areas of the world have very high rates of esophageal cancer (EC). Previous studies have identified western Kenya as a high risk area for EC with an unusual percentage of cases in subjects 30 years of age or younger. To better understand EC in these young patients, we abstracted available data on all 109 young patients diagnosed with EC at Tenwek Hospital, Bomet District, Kenya from January 1996 through June 2009, including age at diagnosis, sex, ethnicity, tumor histology, residence location, and medical interventions. We also attempted to contact all patients or a family member and obtained information on ethnicity, tobacco and alcohol use, family history of cancer, and survival. Sixty (55%) representatives of the 109 young patients were successfully interviewed. The median survival time of these 60 patients was 6.4 months, the most common tumor histology was esophageal squamous cell carcinoma (ESCC) (98%), the M:F ratio was 1.4∶1, and only a few subjects used tobacco (15%) or alcohol (15%). Seventy-nine percent reported a family history of cancer and 43% reported having a family history of EC. In summary, this case series describes the largest number of young EC patients reported to date, and it highlights the uniqueness of the EC experience in western Kenya. Public Library of Science 2010-11-22 /pmc/articles/PMC2989919/ /pubmed/21124934 http://dx.doi.org/10.1371/journal.pone.0014080 Text en This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Dawsey, Sonja P.
Tonui, Stanley
Parker, Robert K.
Fitzwater, John W.
Dawsey, Sanford M.
White, Russell E.
Abnet, Christian C.
Esophageal Cancer in Young People: A Case Series of 109 Cases and Review of the Literature
title Esophageal Cancer in Young People: A Case Series of 109 Cases and Review of the Literature
title_full Esophageal Cancer in Young People: A Case Series of 109 Cases and Review of the Literature
title_fullStr Esophageal Cancer in Young People: A Case Series of 109 Cases and Review of the Literature
title_full_unstemmed Esophageal Cancer in Young People: A Case Series of 109 Cases and Review of the Literature
title_short Esophageal Cancer in Young People: A Case Series of 109 Cases and Review of the Literature
title_sort esophageal cancer in young people: a case series of 109 cases and review of the literature
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989919/
https://www.ncbi.nlm.nih.gov/pubmed/21124934
http://dx.doi.org/10.1371/journal.pone.0014080
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